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Cost International Projects National Projects Bilateral Scientific Cooperation Национални пројекти HORIZON-RIA ИДЕЈЕ позив Proof of Concept Доказ концепта

An Integrated Study of Regional Genetic and Environmental Risk Factors for Major Noncommunicable Diseases in the Serbian Population

Project leader: Dr. Dragan Alavantić

Project collaborators: Dr. Mirjana Gurinović, Dr. Marija Glibetić, Dr. Jasmina Martačić-Debeljak, Dr. Marija Takić

Project number: III 41028

Duration of the project: 2011-2020.

Leading institution: Vinča Institute of Nuclear Sciences

Description of the project:

Collaborators from IMR were engaged in the areas of research on nutragenomics and gene regulation of cardiovascular diseases.

Тип пројекта:

National Projects

Metabolic Effects of Bone Marrow Adipose Tissue on Multiple Myeloma

Project leader: Dr. Drenka Trivanović

Project collaborators: Dr. Ivana Okić Djordjević, Dr. Aleksandra Jauković, Dr. Marijana Kovačić, Dr. Sanja Momčilović, Milena Živanović

Project number:

Duration of the project: 2023-2024.

Leading institution: Julius-Maximilians-Universität Würzburg – Department for Musculoskeletal Tissue Regeneration

Collaborating institution: Institute for Orthopedic Surgery “Banjica”

Description of the project:

Multiple myeloma (MM) is the hematologic malignancy and incurable clonal disease of the plasma cell that grows within the bone marrow (BM) causing destructive bone lesions. As disease of elderly, MM is associated with increased bone marrow adipose tissue (BMAT) that might provide supportive microenvironment for MM cell growth, survival and drug resistance. Since adipocytes were shown to support cancer cell growth by influencing cell mitochondrial activity and lipid metabolism, this project aims to decipher whether BM adipocytes (BMAd) population represents one of the key regulators of MM persistence by controlling fatty acid oxidation (FAO) in MM cells. To address this issue, we will determine the lipid profile of femoral bone marrow, as well as metabolic fitness of plasma and BMAT cells in MM patients. In parallel, lipid and mitochondria exchange at single-cell level will be analyzed in advanced cultures of BMAT and MM cells. Particularly, the role of Kisspeptin-1 receptor signaling in BMAT and MM fatty acid exchange will be explored.

Тип пројекта:

Bilateral Scientific Cooperation

Biological Effects, Nutritional Intake, and Status of Folate and Polyunsaturated Fatty Acids: Improving Nutrition in Serbia

Project leader: Dr. Marija Glibetić

Project collaborators: Dr. Marija Takić, Dr. Milica Zekovic, Dr. Biljana Pokimica, Dr. Tamara Popovic, Dr. Gordana Petrovic-Oggiano, Dr. Jelena Milešević, Dr. Jasmina Martačić-Debeljak, Dr. Marija Knez, Dr. Marija Ranić, Dr. Irena Krga, Dr. Vuk Stevanovic, Dr. Nevena Kardum, Dr. Mirjana Gurinović, Dr. Vesna Vučić, Dr. Aleksandra Arsić, Dr. Danijela Ristić-Medić, Dr. Milica Kojadinović, Dr. Marija Paunović, Marta Despotović

Project number: III 41030

Duration of the project: 2011-2020.

Leading institution: Institute for Biological Research “Siniša Stanković”, University of Belgrade, Faculty of Medicine, University of Belgrade, Faculty of Technology and Metallurgy, University of Belgrade, Institute for Medicinal Plants Research “Dr. Josif Pančić”, Faculty of Economics, University of Belgrade

Description of the project:

The subject of the project is research on the intake and status of folate and polyunsaturated fatty acids (PUFA) in the population of Serbia, which entails 1. literature review to identify at-risk population groups with low intake of folate and PUFA, 2. establishment and validation of methods for assessing intake and status , 3. interventional studies on an animal model, 4. determination of the etiopathogenetic, therapeutic and prophylactic effect of PUFA and folate intake in chronic non-communicable diseases on a human model, 5. market research, producer and consumer perception towards foods enriched with folates and PUFA, 6. dissemination of results scientific and general population.

Тип пројекта:

National Projects

Beneficial Effects of Dietary Bioactive Peptides and Polyphenols on Cardiovascular Health in Humans

Project leader: Dr. Marija Glibetić

Project collaborators: Dr. Nevena Kardum, Dr. Slavica Ranković, Dr. Milica Kojadinovic, Dr. Marija Takić, Dr. Jasmina Martačić-Debeljak, Dr. Aleksandra Konić-Ristić, Dr. Manja Zec

Project number: 312090

Duration of the project: October 2012-September 2016.

Leading institution: Quadram Institute, United Kingdom

Description of the project:

The main objective of the BACCHUS project was to develop tools and resources that will facilitate the generation of robust and exploitable scientific evidence that can be used to support claims of a cause and effect relationship between consumption of bioactive peptides and polyphenols, and beneficial physiological effects related to cardiovascular health in humans. The IMI team primary explored the effects of aronia-polyphenol rich juice consumption on aggregation and activation of thrombocytes in abdominally obese subjects.

Тип пројекта:

International Projects

Food-Based Solutions for Optimal Vitamin D Nutrition and Health Throughout the Life Cycle

Project leader: Dr. Marija Glibetić

Project collaborators: Dr. Vesna Vučić, Dr. Danijela Ristić-Medić, Dr. Aleksandra Arsić, Dr. Jelena Milešević, Dr. Manja Zec, Dr. Mirjana Gurinovic, Dr. Marija Ranić

Project number: 613977

Duration of the project: November 2013-October 2017.

Leading institution: University College Cork, National University of Ireland

Description of the project:

ODIN project provided the evidence to prevent vitamin D deficiency in Europe and improve nutrition and public health through food. By establishing an internationally standardized analytical platform for 25OHD, ODIN measured the distribution of circulating 25OHD and describe the prevalence of vitamin D deficiency in Europe. Using available biobanks and databases from National nutrition surveys ODIN delineated the relative contributions of sun and dietary sources of vitamin D to circulating 25OHD. In support of vitamin D recommendations, ODIN carried out three RCT in pregnant women, children and teenagers and a fourth RCT in ethnic immigrant groups to provide experimental data to specify vitamin D intake requirements.

Тип пројекта:

International Projects

Low-Cost Technologies and Traditional Ingredients for the Production of Affordable, Nutritionally Balanced Foods to Improve Health in Population Groups at Risk of Poverty (CHANCE)

Project leader: Dr. Marija Glibetić

Project collaborators: Dr. Romana Novaković, Dr. Danijela Ristić-Medić, Dr. Mirjana Gurinović, Dr. Jelena Milešević, Dr. Nevena Kardum

Project number: 266331

Duration of the project: February 2011-July 2014.

Leading institution: Alma Mater Studiorum, University of Bologna

Description of the project:

CHANCE project defined an innovative strategy based on a socio-economic study of the composition of the most significant EU populations at-risk-of-poverty and verified the relative existing nutritional deficiency via a holistic approach ensured by metabolomics investigations correlating the non-healthy diet to real metabolism alterations. CHANCE adopted a new multidisciplinary approach, leading to nutritional strategies for the prevention of malnutrition in population groups at risk of poverty. CHANCE aimed at considered a new health value-added diet as a whole by developing food products which could act in concert. The synergic collaboration of nutritionists, food chemists, economists and technologists allowed a robust strategy to by pass all barriers to healthy nutrition by the lab-scale development of affordable but nutritionally-rich food products, new packaging and portioning.

Тип пројекта:

International Projects

The EuroFIR Food Platform: Further Integration, Refinement and Exploitation for Its Long-Term Self-Sustainability

Project leader: Dr. Marija Glibetić

Project collaborators: Dr. Mirjana Gurinović, Dr. Jelena Milešević, Dr. Jasmina Martačić-Debeljak, Dr. Marija Takić

Project number: 265967

Duration of the project: 2011-2013.

Leading institution: Quadram Institute, United Kingdom

Description of the project:

The objective of this project was to further integrate/refine the EuroFIR Food Platform, to improve/support the ways research is undertaken into relationships between food, diets and health in Europe. The focus was on extending application and exploitation of validated food data and tools for pan-European nutrition studies and networked usage, implementation of standards and best practice. This together forms the basis of long-term sustainability through the newly established legal entity EuroFIR AISBL.

Тип пројекта:

International Projects