Immunology
The research carried out in the Immunology Group is focused on аnalysis of structure of immunoglobulins and their reactivity with antigens in physiological conditions and infectious, autoimmune, metabolic diseases, and hematological malignancies. Basic research is carried out in parallel in several directions:
- Immunoglobulin reactivity with microbial antigens with an aim to define the interconnection between this antimicrobial reactivity and reactivity with self-antigens.
- Molecular constituents of the peripheral blood immune complex, by applying immunochemical, biochemical and “classical” physicochemical methods.
- Implementation of photon correlation spectroscopy (synonym Dynamic Light Scattering; DLS) for analysis of the size of the immune complex.
- Morphological and rheological characteristics of erythrocytes, as cells of crucial importance for the removal of immunocomplexes (immune adherence)
- Effects on cellular and molecular environment on level and structure of monoclonal immunoglobulin secreted by myeloma cell lines
- Hemoglobin as heme iron-based: 1) Food supplement and 2) Cell culture aditive
- Effectes of zeolites as food supplement on cattle immunity
NEXT THREE YEARS
In depth analysis of immunoglobulins in physiological conditions and in infectious, autoimmune, metabolic and malignant diseases by opening new directions of research:
- Study of the role of immune complexes, as the main effectors of the humoral branch of the immune response, as modulators of neutrophils’ function.
- Analysis of the antimicrobial reactivity of immunoglobulins of the oral region with the aim of defining their influence on the development of caries.
- Identification of (auto)antigens in immunocomplexes by mass spectrometry.
- Analysis of variable regions of immunoglobulin genes and analysis of polymorphism of Fc receptors with the aim to identify combinations of their genes’ variants that may be of pathological importance in the mentioned diseases.
- Erythrocytes as immuno- and hemo-compatible delivery systems for drug of significance for immune system function.
Head of the Research Group
Group Members
Latest PROJECTS
Project HEMMAGINERO, No. 6066079 “Hemoglobin-based spectroscopy and nonlinear imaging of erythrocytes and their membranes as emerging diagnostic tool” from Program for excellent projects of young researchers in Republic of Serbia (PROMIS) funded by The Science Fund of the Republic of Serbia. (I. Drvenica, the project participant)
Latest RESEARCH PAPERS
Immune complexes
- Djukić T, Drvenica I, Kovačić M, Minić R, Vučetić D, Majerič D, Šefik-Bukilica M, Savić O, Bugarski B, Ilić V. Dynamic light scattering analysis of immune complexes in sera of rheumatoid arthritis patients. Analytical Biochemistry. 2023, 674: 115194. doi: 10.1016/j.ab.2023.11519
- Kovačić M, Fratrić N, Arsić A, Mojsilović S, Drvenica I, Marković D, Maslovarić I, Grujić Milanović J, Ivanov M, Ilić V. Structural characteristics of circulating immune complexes in calves with bronchopneumonia: Impact on the quiescent leukocytes. Research in Veterinary Science. 2020, 133: 63-74 doi: 10.1016/j.rvsc.2020.09.004
Immunoglobulins and microorganisms
- Knežević S, Kosanović D, Dragačević L, Živković I, Ilić V, Hajduković L, Savić O, Minić R. Age and gender associated changes in immunoglobulin subclass levels specific to S. pneumoniae, serotype 1. Comparative Immunology, Microbiology and Infectious Diseases, 2022, 87: 101834. doi: 10.1016/j.cimid.2022.101834
- Nikodijević S, Blagojević V, Ćuruvija I, Kosanović D, Djukić T, Djordjević B, Ilić V, Minić R. Selectivity of polyclonal repertoire of anti-microbial IgA and its subclasses in saliva and serum in humans. Scandinavian Journal of Immunology. 2022, 96(6): e13223. doi: 10.1111/sji.13223
Hemoglobin and erythrocytes:
- Radmilović MD, Drvenica IT, Rabasović MD, Ilić VL, Pavlović D, Oasa S, Vukojević V, Perić M, Nikolić SN, Krmpot AJ. Interactions of ultrashort laser pulses with hemoglobin: Photophysical aspects and potential applications. International Journal of Biological Macromolecules. 2023, 244:125312. doi: 10.1016/j.ijbiomac.2023.125312.
- Stančić AZ, Drvenica IT, Obradović HN, Bugarski BM, Ilić VL, Bugarski DS. Native bovine hemoglobin reduces differentiation capacity of mesenchymal stromal cells in vitro. Int J Biol Macromol. 2020 Feb 1;144:909-920. doi: 10.1016/j.ijbiomac.2019.09.167.
Zeolites as cattle food supplement
- Stojić M, Ilić V, Kovačić M, Gvozdić D, Stajković S, Vejnović B, Savić O, Fratrić N. Effects of oral supplementation with organically modified clinoptilolite during prepartum period on colostrum quality in primiparous dairy cows. Journal of Dairy Research. 2020, 87(4): 429-435. doi: 10.1017/S0022029920001077
- Drvenica I, Stojić M, Fratrić N, Kovačić M, Grujić-Milanović J, Vejnović B, Marković D, Gvozdić D, Ilić V. Oral supplementation with organically modified clinoptilolite during prepartum period influences the redox status of peripheral blood and colostrum of primiparous dairy cows. Italian Journal of Animal Science. 2022, 21(1): 847-58. doi: 10.1080/1828051X.2022.2070034
Neutrophils
- Marković D, Maslovarić I, Djikić D, Čokić VP. Neutrophil Death in Myeloproliferative Neoplasms: Shedding More Light on Neutrophils as a Pathogenic Link to Chronic Inflammation. International Journal of Molecular Sciences. 2022; 23(3): 1490. doi: 10.3390/ijms23031490.
- Marković DC, Maslovarić IS, Kovačić M, Vignjević Petrinović S, Ilić VL. Putative Role of Neutrophil Extracellular Trap Formation in Chronic Myeloproliferative Neoplasms. International Journal of Molecular Sciences, 24(5): 4497. doi: 10.3390/ijms24054497.
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