Projects

Pain Assessment in Patients with Impaired Cognition, Especially Dementia

Project leader: Dr. Stefan Lautenbacher

Project collaborators: Dr. Saša Filipović, Dr. Jovana Bjekić

Project number: TD1005

Duration of the project: 2011-2015.

Leading institution: University of Bamberg, LUMC, Cyclotron Research CentrenUniversite de Liege, Ghent University Hospital, University of Nicosia, Charles University Third Faculty of Medicine, Aarhus University Hospital, Faculty of Medicine, University Hospital, Clermont-Ferrand, France, University of Bamberg, National University of Ireland, Tel-Aviv University, Health Sciences Faculty, Israel, University of Turin and National Institute of Neuroscience, Academic Centre for Dentistry, University of BergenDepartment of Public Health and Primary Health Care, Clinical Hospital of Psychiatry, Medicine and Pharmacy University “Carol Davila”, Institute for Medical Research – University of Belgrade, Universitat Autònoma de Barcelona, Universitat Rovira i Virgili, University Hospital Geneva, University College London Research, University of Greenwich Centre of Positive Ageing, University of Liège, Aalborg University, University of Bamberg, Malteser Hospital, Tel aviv University, University of Torino, University of Turin, University of Bergen, University of Belgrade Faculty of Medicine, National Ageing Research Institute, RMIT University.

Description of the project:

The project was established to facilitate the development of a comprehensive and internationally agreed-on assessment toolkit for older adults targeting the various subtypes of dementia and various aspects of pain, including pain diagnostics, cognitive examination and guidelines for proper assessment. The collaboration created a clinical bedside tool for pain assessment in patients with dementia and cognitive impairments (PAIC). The PAIC tool is aimed to be adapted and validated for use across Europe in order to facilitate common research and to be used in clinical/health care settings.

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Collaboration of Aphasia Trialists (CATs)

Project leader: Dr. Marion Brody, Dr. Saša Filipović

Project collaborators: Dr. Jasmina Vuksanović, Dr. Jovana Bjekić, Dr. Marko Živanović

Project number: IS1208

Duration of the project: 2013-ongoing

Leading institution: Glasgow Caledonian University NMAHP Research Unit, Erasmus University Medical Centre, National and Kapodistrian University of Athens, Karolinska Institutet, University of Southern Denmark, Universtiy of Antwerp, University of Zagreb, University of Cyprus, University of Copenhagen, University of Tampere, Ecole Normale Superieure, University of Lille, University of Muenster, Freie Universitat Berlin, University of Oldenburg, Cyprus University of Technology, National and Kapodistrian University of Athens, Budapest University of Technology and Economics, Eötvös Loránd University, University of Limerick, Trinity College Dublin, Loewenstein Rehabilitation Hospital, Bar Ilan University, University of Venice ca’bembo, University of Verona, Vytautas Magnus University, University of Malta, University of Groningen, Statped sørøst, University of Oslo, University of Aveiro, University of Trento, Institute for Medical Research – University of Belgrade, Universitat Autònoma de Barcelona, University of Valencia, University of Gothenburg, University of Manchester, Charite Universitätsmedizin Berlin, University of PatrasMegalou Alexandrou, National and Kapodistrian University of Athens, University Of PatrasDepartment of Speech and Language Therapyt, Rijndam rehabilitation center, St.Petersburg State University, National Research University Higher School of Economics, St.Petersburg State Pediatric Medical University, The University of Queensland, University of the Witwatersrand, University of Canterbury

Description of the project:

The project seeks to improve our understanding of aphasia as it relates to predictors and prognosis, intervention effectiveness and social impact and re-integration for people with aphasia. It works to increase the availability and validity of multilingual assessments and outcome measures relating to aphasia. In this way the collaboration supports international research activities and increase the availability of clinical tools for people with aphasia who do not speak English and their healthcare professionals. The project gathered scientist form over 30 countries to work within six main groups: WG1 Aphasia Datasets; WG2 Aphasia assessment and outcomes; WG3 Prognosis and predictors of recovery; WG4 Effectiveness of interventions; WG5 Societal impact; W6 Cognition. One of the major outcomes so far has been the development of multilingual aphasia measurement instruments and recommendations for measurement of outcomes in adults with post-stroke aphasia (ROMA) within aphasia treatment studies.

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The Grain-Based Functional Products for People with Metabolic Disorders

Project leader: Dr. Ana Marija Mandić

Project collaborators: Dr. Tamara Popović, Dr. Aleksandra Arsić

Project number: TR31029

Duration of the project: 2011-2020.

Leading institution: Institute of Food Technology in Novi Sad (FINS)

Description of the project:

Products made using several herbal mixtures was studied, and in the last year the algae Spirulina. The characterization and detailed examination of the mixtures themselves was the project task of FINS, while the task of the aforementioned researchers from IMI, was to determine biochemical parameters of the blood of animals before and after treatment as well as profile of fatty acids phospholipids of serum and organs (liver, brain) during following up studies of effects of exanimated products.

Тип пројекта:

National Projects

The Neural Architecture of Consciousness

Project leader: Dr. Kristian Sandberg, Dr. Jovana Bjekić

Project collaborators: Dr. Saša Filipović, Dr. Katarina Vulić, Dr. Marko Živanović, Dr. Uroš Konstantinović, Dunja Paunović

Project number: CA18106

Duration of the project: 2019-2023.

Leading Institution: Aarhus University, Aristotle University of Thessaloniki, Babeș-Bolyai University, Bar-Ilan University, Bezalel Academy of Arts and Design, Cardiff University, Central European Institute of Technology, Charité Berlin, Comenius University in Bratislava, Democritus University of Thrace, Department of Psychology, École Normale Supérieure, Faculty of Science, Eötvös Loránd University, Fondazione IRCCS Istituto Neurologico Carlo Besta, Instituto Superior de Engenharia do Porto, Institute of Information and Communication Technologies, University of Belgrade, Institute of Neurobiology, Instituto de Investigação em Ciências da Vida e da Saúde, Jagiellonian University, Faculty of Engineering, Karadeniz Technical University, Lithuanian Energy Institute, Faculty of Medicine, University of East Sarajevo, Nencki Institute of Experimental Biology, Radboud University Medical Center, Tallinn University of Technology, The Academy of Applied Preschool Teaching and Health Studies, The Cyprus Institute of Neurology and Genetics, Trinity College Dublin, UCL, Universidad del País Vasco/Euskal Herriko Unibertsitatea, University of Malta, Roma Tre University, University Medical Center, Georg-August-Universität Göttingen, University of Bergen, University of Jyväskylä, GIGA Institute, University of Liège, Medical School, University of Nicosia, University of Oslo, University of Salzburg, University of Tartu, University of Vic – Central University of Catalonia, University of Zagreb, University of Zurich and ETH Zurich, Université Libre de Bruxelles, Vilnius University, İnönü University

Description of the project:

The project sets to explore the neural underpinnings of consciousness through large scale muliticenter studies that focus on collecting MRI data alongsied wide spectrum of behavioural outcomes to build predictive models for normal and pathological cognitive functioning. The colleboration is organized in seven groups: WG1 Neuroarchitectural mapping, WG2 Statistical methods, WG3 – Conscious perception, WG4 Metacognition, WG5 Consciousness, learning, and memory, WG6 – Clinical measures of consciousness, and WG7 – Large-scale data collection – coorinating large sacle data collection sites in Aarhus (Denmark), Krakow (Poland), Brno (Czech Republic), Chiba (Japan) and Cardiff (UK).

Тип пројекта:

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From Brain Waves to Memory Boost: Memory Enhancement by Personalized Frequency-Modulated Noninvasive Brain Stimulation

Project leader: Dr. Jovana Bjekić

Project collaborators: Dr. Katarina Vulić, Dr. Uroš Konstantinović, Dr. Saša Filipović, Dunja Paunović

Project number: 6058808

Duration of the project: 2020-2022.

Leading institution: Institute for Medical Research, University of Belgrade

Description of the project:

This project seeks to enhance the impact of transcranial direct current stimulation (tDCS) on memory by personalizing and optimizing the stimulation protocol for the parieto-hippocampal neural network. The project proposes an electrode positioning method that targets associative memory, a crucial function for remembering connected information. Unfortunately, associative memory deteriorates with age and is compromised in individuals with neurodegenerative conditions. The project also developed new frequency-modulated protocols and assessed their neurophysiological and behavioral effects. To further enhance the efficacy of the stimulation, the protocol was personalized to the individual theta rhythm. Theta rhythm is a neurophysiological marker of memory that appears in the electroencephalographic record when individuals attempt to remember or recall something. This project’s goal is to improve memory outcomes through customized and optimized tDCS protocols for the parieto-hippocampal neural network.

Тип пројекта:

National Projects

Establishment of an ALPL Gene-Deficient Patient-Derived Cell Line for Investigation of the Metabolic Background of Hip Osteoarthritis

Project leader: Dr. Drenka Trivanović

Project collaborators: Dr. Slavko Mojsilović, Dr. Ivana Okić Đorđević, Dr. Aleksandra Jauković, Dr. Tamara Kukolj, Dr. Hristina Obradović, Dr. Anđelija Petrović, Milena Živanović

Project number: Q422RSV70

Duration of the project: January 2023-December 2023.

Leading institution: Institute for Medical Research, University of Belgrade

Description of the project:

The role of tissue non-specific alkaline phosphatase (TNAP) in osteoarthritis (OA) has not been fully clarified. High expression of TNAP as ectonucleotidase is associated with ATP degradation and production of adenosine, which can again trigger and support inflammatory calcifying conditions, but also decrease mineralization of the subchondral bone in OA. Thus, we anticipate that TNAP beyond its well-known contribution to mineralization, participates in profiling of cellular metabolism. To verify the assumption that TNAP controls metabolism of cells from OA patients, we attempt to apply genome editing (GE) techniques to silence and knockout Alpl gene in OA patient-derived mesenchymal stromal cells. We will perform Alpl gene silencing (commercially available siRNA) and CRISPR/Cas9 technique to establish OA patient-derived GE cell lines (clones) with Alpl gene silencing/knockout for investigation of metabolic roles of TNAP in OA patients.

Тип пројекта:

International Projects

Twinning for Excellence in Non-Invasive Brain Stimulation in the Western Balkans

Project leader: Dr. Saša R. Filipović, Dr. Jovana Bjekić

Project collaborators: Dr. Marko Živanović, Dr. Uroš Konstantinović, Dunja Paunović, Katarina Vulić, Marija Stanković, Jasmina Vuksanović, Milan Jelić, Milena Spoa, Dagana Stojić, Kontantin Tomić, Bojana Đukć

Project number: 101059369

Duration of the project: 2022-2025.

Leading institution: Institute for Medical Research, University of Belgrade

Description of the project:

TWINNIBS aims to strengthen the Institute for Medical Research – IMR’s research and innovation (R&I) as well as research management and administration capacities and to develop it into a prospective leading partner in international consortia that can attract strategic investments and R&I funding. TWINNIBS will promote interest in neuroscience research in Serbia and the region, and help to advance it, focusing on the multidisciplinary field of non-invasive brain stimulation (NIBS). NIBS is a set of techniques for transcranial (non-invasive) modulation of the activity in the specific brain areas and the large-scale brain networks to which they contribute. This is an innovative approach to neuroscience research and, ultimately, clinical treatment of a wide spectrum of neuropsychiatric conditions. TWNINIBS will be a coordination and support tool for IMR to bring NIBS research in Serbia to a new level by partnering with leading European R&I institutions from Denmark, Italy, Germany and Austria. TWNNIBS will include a comprehensive set of cooperation and coordination activities to strengthen the scientific and technological capacities of IMR, including short term mobility, virtual and in-person short term expert visits, workshops and boot-camps. A series of collaborative small-scale projects will be conducted with the personalisation of NIBS as an overarching theme. TWINNIBS will strengthen the IMR research management and administration capacities and foster organizational changes. The Centre for NIBS as well as R&I Project Management Unit will be established within the IMR. TWINNIBS will have a substantial scientific, economic/technological, and societal impact towards outcomes specified in this topic as well as a long-term impact on the R&I in the European space, with a special focus on the Western Balkans region. To realise the full potential of the TWINNIBS project a comprehensive set of communication, dissemination, and exploitation measures will be implemented.

Тип пројекта:

International Projects

Application of Biotechnological Methods in the Sustainable Use of Agro-Products

Project leader: Dr. Suzana Dimitrijević-Branković

Project collaborators: Dr. Marija Ranić

Project number: TR31035

Duration of the project: 2011-2020.

Leading institution: Faculty of Technology and Metallurgy, University of Belgrade

Description of the project:

In cooperation with Biochemical Engineering and Biotechnology, Marija Ranić carried out research related to the processes of extraction of biologically active substances within the project in the field of technological development TR31035. Her research included the optimization of methods for extraction of biologically active components of waste coffee, using microwave radiation. The aim of these studies was to test the possibility of full and multiple utilization of waste materials. Obtained data contribute to increase of coffee waste value and reducing the demands, both technical and economic, for its care.

Тип пројекта:

National Projects
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