Neuroendocrinology

This cross-disciplinary research group studies neuroendocrine-immune interactions during ontogenesis, stress, and inflammation. The main areas of research are:

  1. Cellular and molecular mechanisms underlying erythropoietic response to chronic psychological stress
  2. Interactions between macrophages and tissue-specific mesenchymal stem cells during stress and inflammation
  3. Roles of nitric-oxide and purinergic signalling in macrophage-mesenchymal stem cells interactions during stress erythropoiesis
  4. Appearance, localization, density of endocrine cells in human stomach and pancreas during prenatal and early postnatal development

NEXT THREE YEARS

Considering the significant implication of neuroendocrine-immune dysfunction in cancer development and progression, as well as the fact that the global burden of breast cancer is rising fast, we plan to use the experimental model of breast cancer and focus future research on the mechanisms of neuroendocrine-immune interactions in the tumor microenvironment. This research will include:

  • Molecular mechanisms underlying the tumor-promoting activity of stress erythropoiesis pathways
  • Immunomodulatory properties of stress erythroid progenitors

 

 

  • Roles of glucocorticoids and purinergic signaling on macrophages polarization and their interactions with mesenchymal stem cells within the tumor microenvironment
  • Therapeutic potential of inhibiting ineffective SE in suppressing breast cancer growth and progression

Head of the Research Group

Group Members

Latest PROJECTS

2023-2026 Anti-Inflammatory Dietary intervention in breast cancer patients receiving aromatase inhibitors – AID

2024-2026 Determining the Potential of Placental Tissue Derivatives for Use in Post-Mastectomy Breast Reconstruction: Development of a 3D-Printed Bioscaffold

2023-2025 Bilateral project (Serbia – Slovenia): Development of mucoadhesive films whit amniotic membrane homogenate for the potential application in oral tissue regeneration.

2023-2024 Bilateral project (Serbia-Germany): Metabolic effects of bone marrow adipose tissue on multiple myeloma. German Academic Exchange Service (DAAD).

COST actions:

CA21130 – P2X receptors as a therapeutic opportunity (PRESTO)

CA21113 – Genome Editing to Treat Humans Diseases (GenE-Humdi)

All projects of this group

Latest RESEARCH PAPERS

Momčilović S, Bogdanović A, Milošević MS, Mojsilović S, Marković DC, Kočović DM, Vignjević Petrinović S. Macrophages provide essential support for erythropoiesis, and extracellular ATP contributes to a erythropoiesis-supportive microenvironment during repeated psychological stress. Int J Mol Sci 2023; 24(14):11373.

 

Vignjević Petrinović S, Milošević MS, Marković D, Momčilović S. Interplay between stress and cancer-A focus on inflammation. Front Physiol 2023; 14:1119095.

 

Vignjević Petrinović S, Jauković A, Milošević M, Bugarski D, Budeč M. Targeting stress erythropoiesis pathways in cancer. Front Physiol 2022; 13:844042.

 

Vignjević Petrinović S, Budeč M, Marković D, Mitrović Ajtić O, Jovčić G, Milošević M, Momčilović S, Čokić V. Nitric oxide-dependent expansion of erythroid progenitors in a murine model of chronic psychological stress. Histochem Cell Biol 2020;153(6):457-468

All papers

Interested in working with our research group?

Our team of experts is committed to advancing health and wellness through innovative research.
If you would like to join our team or cooperate with us, please contact us.
We look forward to cooperation with you!

 

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