Molecular Oncology

Scientific research work is focused on the study of the molecular mechanisms of the pathogenesis of hematological malignancies, primarily myeloproliferative neoplasms, as well as the occurrence of thrombosis in patients with acute or chronic inflammation. Research is currently focused in five directions:

  1. examination of inflammation and fibrosis in myeloproliferative neoplasms;
  2. examination of the mechanism of action of hydroxyurea cytostatics in mouse knockout models and human cell lines;
  3. examination of the mechanisms of thrombosis in hematological malignancies (Hodgkin's lymphoma, non-Hodgkin's lymphoma, acute myeloid leukemia, multiple myeloma), which are mediated by the interaction between inflammatory markers and endothelial cells, platelets and leukocytes;
  4. investigation of gender dependence in hyperinflammatory response in patients with COVID-19.
  5. examination of oxidative stress factors and activation of inflammatory signaling pathways in patients with colon adenocarcinoma.

NEXT THREE YEARS:

In the following research period, in addition to the mentioned current research problems, we will also deal with the examination of:

  • oncogenesis mediated by the EPSTEIN-BARR virus in chronic lymphocytic leukemia, as well as predicting the clinical course of the disease and the initiation of therapy through machine learning;- genetic
  • predispositions for hereditary and secondary erythrocytosis;
  • standardization of diagnosis of hemoglobinopathies.

Head of the Research Group

Principal research fellow

Vladan Čokić

Principal research fellow

Vladan Čokić

Vladan Čokić, MD, PhD, principal research fellow, full member of the Academy of Medical Sciences of the Serbian Medical Association. From 1999 to 2004, he was employed as an external fellow in the Division of Molecular Medicine at the NIDDK, NIH, USA. Defended his PhD thesis in 2009 in Hematology at the Faculty of Medicine of the University of Belgrade. Residency in Internal Medicine, at the Faculty of Medicine, University of Belgrade, was completed in 2011. From 2011-2019. principal investigator of the national project granted by the Ministry of Education, Science and Technological Development of the Republic of Serbia (RS). Partner in international projects (SCOPES 2014-2016, COST 2014-2018). Since 2017, head of the Molecular Oncology Group at the Institute for Medical Research. A principal investigator of the national COVID-19 project (2021-2022) and senior researcher in the national PROMIS (2020-2022) and IDEJE (2022-2025) projects of the Science Fund of the RS.

Email:vl@imi.bg.ac.rs

Group Members

Principal research fellow

Vladan Čokić
Senior research associate

Olivera Mitrović Ajtić
Research associate

Miloš Diklić

Principal research fellow

Vladan Čokić

Vladan Čokić, MD, PhD, principal research fellow, full member of the Academy of Medical Sciences of the Serbian Medical Association. From 1999 to 2004, he was employed as an external fellow in the Division of Molecular Medicine at the NIDDK, NIH, USA. Defended his PhD thesis in 2009 in Hematology at the Faculty of Medicine of the University of Belgrade. Residency in Internal Medicine, at the Faculty of Medicine, University of Belgrade, was completed in 2011. From 2011-2019. principal investigator of the national project granted by the Ministry of Education, Science and Technological Development of the Republic of Serbia (RS). Partner in international projects (SCOPES 2014-2016, COST 2014-2018). Since 2017, head of the Molecular Oncology Group at the Institute for Medical Research. A principal investigator of the national COVID-19 project (2021-2022) and senior researcher in the national PROMIS (2020-2022) and IDEJE (2022-2025) projects of the Science Fund of the RS.

Email:vl@imi.bg.ac.rs

Senior research associate

Olivera Mitrović Ajtić

Dr. Olivera Mitrović Ajtić, PhD in biology, in the group for molecular oncology. Her research is focused on examining chronic inflammation and angiogenesis in hematological malignancies. She also studies the relationship between inflammation and the appearance of thrombosis in various hematological malignancies. She is interested in investigating signaling pathways and molecular mechanisms underlying malignant transformation in hematological malignancies.

Email:oliveram@imi.bg.ac.rs

Research associate

Miloš Diklić

Miloš Diklić is a doctor of biological sciences (molecular biology) in the group for molecular oncology. His research includes examining chronic inflammation as a mechanism of pathogenesis of hematological malignancies and colon cancer. Areas of interest are gene expression, RNA interference and microRNA in malignancies and application of PCR and qPCR in molecular diagnostics.

Email:milos.diklic@imi.bg.ac.rs

Latest PROJECTS

All projects of this group

Latest RESEARCH PAPERS

All papers

Interested in working with our research group?

Our team of experts is committed to advancing health and wellness through innovative research.
If you would like to join our team or cooperate with us, please contact us.
We look forward to cooperation with you!

 

This site is registered on wpml.org as a development site.