International Projects Archives - Institute for Medical Research

Synergistic education of parents with children with special needs

The project aims to empower parents/caregivers of children with special needs in daily life, improve their parental skills and social inclusion, health and quality of life. Objectives are to use innovative educational approach for improving parental skills in dealing with children with special needs, with a newly created comprehensive training curiculum and materials and online platform for continuous e-learning in line with the parents’ individual needs and expectations.

Тип пројекта:

International Projects

European Food Safety Authority (EFSA): Support to National Dietary Surveys in Compliance with the EU Menu methodology (sixth support) “The children’s survey”, including subjects from three months up to 9 years old

Project leader : dr Marija Glibetić

Project collaborators:

Marija Takić, Milica Zekovic, Biljana Pokimica, Tamara Popovic, Gordana Petrovic-Oggiano, Jelena Milešević, Jasmina Martačić-Debeljak, Marija Knez, Marija Ranić, Irena Krga, Vuk Stevanovic, Marta Despotović, Nevena Kardum, Mirjana Gurinović, Marija Glibetić

Project number: OC/EFSA/DATA/2016/02

Duration of the project: 2016-2022.

Leading Institution:

Description of the project:

The aim of this project was to develop a methodology to be used in a national survey of food consumption in accordance with the guidelines of the European Food Safety Agency (EFSA) in accordance with the methodology of the EU menu, to prepare and provide EFSA with national protocols and related documents, and in in the first phase, a test-pilot data collection was carried out. In addition, data on food consumption and related information collected during the survey in accordance with the format required by EFSA were prepared and transmitted to EFSA including data on food packaging materials.

Тип пројекта:

International Projects

European Food Safety Authority (EFSA): Support to National Dietary Surveys in Compliance with the EU Menu methodology (sixth support) “The adults’ survey”, including subjects from 10 to 74 years old

Project leader : dr Mirjana Gurinović

Project collaborators:

Project number: OC/EFSA/DATA/2016/03

Duration of the project: 2016-2022.

Leading Institution:

Description of the project:

The objective of this project was to develop the methodology to be used in the national food consumption survey according to the European Food Safety Authority (EFSA) guidance on the EU Menu methodology, to prepare and provide to EFSA the national protocols and related documents, and to pilot and carry out the data collection. In addition, the food consumption data and related information collected during the survey according to the format, required by EFSA, were prepared and transferred to EFSA including data about packaging materials.

Тип пројекта:

International Projects

Development of mucoadhesive films with amniotic membrane homogenate for the potential application in oral tissue regeneration

Project leader: Dr Ivana Okić Đorđević

Project collaborators:

Dr Hristina Obradović, dr Drenka Trivanović, dr Ivana Drvenica, dr med Sanja Momčilović, number: 337-00-110/2023-05/36

Duration of the project: Jul 2023 – Jun 2025

Leading Institution:

Institute for medical Research, University of Belgrade

Collaborating Institution: Institute of cell biology, University of Ljubljana

Description of the project:

Human amniotic membrane (hAM) is an available, inexpensive, and biocompatible collagen-based extracellular matrix with the cells derived from human placenta. hAM and its derivatives possess anti-inflammatory and regenerative properties. Until now, hAM has been used for post-operative and post-traumatic skin defects, intra-oral and genital reconstruction, and ophthalmologic disorders.

In recent decades, the regenerative and modulatory properties of stem cells (SCs) have gained the attention of scientists indicating the possibility of their use in cell therapy. Periodontal ligament SCs (PDLSCs), obtained after tooth extraction for orthodontic reasons are recently discovered cells playing a crucial role in oral tissue homeostasis. Since the outcomes of currently available wound healing treatment approaches of oral tissues are expensive and sometimes not predictable, the search for new molecules with regenerative potential is an important goal in oral tissue regeneration. For this purpose, the objectives of this project include the influence of hAM on wound healing and regenerative potential of PDLSCs.

Тип пројекта:

International Projects

Establishing of Alpl gene-deficient patient cell line for investigation of metabolic background of hip osteoarthritis

Project leader: Dr Trivanović Drenka

Project collaborators:

Dr Slavko Mojsilović, dr Ivana Okić-Đorđević, dr Aleksandra Jauković, dr Tamara Kukolj, dr Hristina Obradović, Anđelija Petrović, Milena Živanović

Project number: Q422RSV70

Duration of the project: January 2023 – December 2023

Leading Institution:

Institut za medicinska istraživanja Univerziteta u Beogradu

Description of the project:

The role of tissue non-specific alkaline phosphatase (TNAP) in osteoarthritis (OA) has not been fully clarified. High expression of TNAP as ectonucleotidase is associated with ATP degradation and production of adenosine, which can again trigger and support inflammatory calcifying conditions, but also decrease mineralization of the subchondral bone in OA. Thus, we anticipate that TNAP beyond its well-known contribution to mineralization, participates in profiling of cellular metabolism. To verify the assumption that TNAP controls metabolism of cells from OA patients, we attempt to apply genome editing (GE) techniques to silence and knockout Alpl gene in OA patient-derived mesenchymal stromal cells. We will perform Alpl gene silencing (commercially available siRNA) and CRISPR/Cas9 technique to establish OA patient-derived GE cell lines (clones) with Alpl gene silencing/knockout for investigation of metabolic roles of TNAP in OA patients.

Тип пројекта:

International Projects

Twinning for excellence in non-invasive brain stimulation in Western Balkans

Project leaders : Saša R. Filipović and Jovana Bjekić

Project collaborators:

Saša R. Filipović , Jovana Bjekić, Jelena Ristić, Uroš Konstantinović, Marija Stanković, Dunja Paunović, Jasmina Vuksanović, Milan Jelić, Milica Ninković, Bojana Đukić, Ivana Paunović, Teodora Puletić, Miroslav Kovač

Project number: 101059369

Duration of the project: 01. 09. 2022 – 31. 08. 2025

Leading Institution: Institute for Medical Research, University of Belgrade, Serbia

Description of the project:

TWINNIBS, a project aimed at strengthening the Institute for Medical Research’s (IMR) research and innovation (R&I) capacities, is set to transform Serbia’s neuroscience research by focusing on non-invasive brain stimulation (NIBS). NIBS techniques modulate the activity in specific brain areas and large-scale brain networks to treat neuropsychiatric conditions. TWINNIBS will coordinate with leading R&I institutions from Denmark, Italy, Germany, and Austria to conduct collaborative small-scale projects, with the personalization of NIBS as an overarching theme. The project includes a comprehensive set of cooperation and coordination activities to strengthen the scientific and technological capacities of IMR. TWINNIBS will establish the Centre for NIBS and R&I Project Management Unit within the IMR to foster organizational changes and strengthen research management and administration capacities. The project’s impact will be significant, not just in scientific, economic/technological and societal outcomes, but also in the long-term R&I of the Western Balkans region.

Тип пројекта:

International Projects

Metabolic effects of bone marrow adipose tissue on multiple myeloma

Project leader : Dr Trivanović Drenka

Project collaborators:

Dr Ivana Okić Djordjević, dr Aleksandra Jauković, dr Marijana Kovačić, Sanja Momčilović doktorand, Milena Živanović doktorand

Project number:

Duration of the project: 2023 – 2024

Leading Institution:

Julius-Maximilians-Universität Würzburg – Department for Musculoskeletal Tissue Regeneration
Institut za ortopediju ”Banjica”

Description of the project:

Multiple myeloma (MM) is the hematologic malignancy and incurable clonal disease of the plasma cell that grows within the bone marrow (BM) causing destructive bone lesions. As disease of elderly, MM is associated with increased bone marrow adipose tissue (BMAT) that might provide supportive microenvironment for MM cell growth, survival and drug resistance. Since adipocytes were shown to support cancer cell growth by influencing cell mitochondrial activity and lipid metabolism, this project aims to decipher whether BM adipocytes (BMAd) population represents one of the key regulators of MM persistence by controlling fatty acid oxidation (FAO) in MM cells. To address this issue, we will determine the lipid profile of femoral bone marrow, as well as metabolic fitness of plasma and BMAT cells in MM patients. In parallel, lipid and mitochondria exchange at single-cell level will be analyzed in advanced cultures of BMAT and MM cells. Particularly, the role of Kisspeptin-1 receptor signaling in BMAT and MM fatty acid exchange will be explored.

Тип пројекта:

International Projects

Beneficial effects of dietary bioactive peptides and polyphenols on CVD health in humans

Project leader : dr Marija Glibetić

Project collaborators:

Nevena Kardum, Slavica Ranković, Milica Kojadinovic, Marija Takić, Jasmina Martačić-Debeljak, Marija Glibetić, Aleksandra Konić-Ristić, Manja Zec

Project number: 312090

Duration of the project: October 2012 – September 2016

Leading Institution:

Quadram Institute Bioscience United Kingdom

Description of the project:

The main objective of the BACCHUS project was to develop tools and resources that will facilitate the generation of robust and exploitable scientific evidence that can be used to support claims of a cause and effect relationship between consumption of bioactive peptides and polyphenols, and beneficial physiological effects related to cardiovascular health in humans. The IMI team primary explored the effects of aronia-polyphenol rich juice consumption on aggregation and activation of thrombocytes in abdominally obese subjects.

Тип пројекта:

International Projects

Food-based solutions for optimal vitamin D nutrition and health through the life cycle

Project leader: dr Marija Glibetić

Project collaborators:

Vesna Vučić, Danijela Ristić-Medić, Aleksandra Arsić, Jelena Milešević, Manja Zec, Mirjana Gurinovic, Marija Ranić, Marija Glibetić

Project number: 613977

Duration of the project: November 2013-October 2017

Leading Institution: UNIVERSITY COLLEGE CORK – NATIONAL UNIVERSITY OF IRELAND, CORK Address

Description of the project:

ODIN project provided the evidence to prevent vitamin D deficiency in Europe and improve nutrition and public health through food. By establishing an internationally standardized analytical platform for 25OHD, ODIN measured the distribution of circulating 25OHD and describe the prevalence of vitamin D deficiency in Europe. Using available biobanks and databases from National nutrition surveys ODIN delineated the relative contributions of sun and dietary sources of vitamin D to circulating 25OHD. In support of vitamin D recommendations, ODIN carried out three RCT in pregnant women, children and teenagers and a fourth RCT in ethnic immigrant groups to provide experimental data to specify vitamin D intake requirements.

Тип пројекта:

International Projects

1 2 3 4