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From Molecules to Brain Health: A Framework for European Excellence in Translational Neuroscience (BRAINFRAME)

Project leader: Dr. Inga Griskova Bulanova, Dr. Milica Zeković

Project collaborators: Dr. Jovana Bjekić, Dr. Uroš Konstantinović, Bojana Đukić, Marija Stanković, Milena Spoa, Dragana Stojić, Konstantin Tomić

Duration of the project: 2027-2031.

Leading institution: Vilnius University (Lithuania), Institute of Pharmacology of the Polish Academy of Sciences (Poland), Faculty of Medicine, University of Lisbon (Portugal), Barcelona Clinical Research Foundation – August Pi i Sunyer Biomedical Research Institute (Spain), Institute for Medical Research, University of Belgrade (Serbia), Karolinska Institutet (Sweden), SKEIN (Ukraine), UAB Orientos (Lithuania), Masaryk University (Czech Republic)

Description of the project:

BRAINFRAME aims to modernise and strengthen the research and innovation (R&I) dimension of the Institute for Medical Research (IMR) by establishing a sustainable, interconnected framework for excellence in translational neuroscience. The project bridges the entire translational continuum—from molecular and cellular discoveries through organoid and systems-level models to human validation and clinical practice. Within this integrated research environment, IMR leads specialized efforts in mechanistically oriented TES-EEG research, utilizing advanced neuromodulation and electrophysiological techniques to investigate the fundamental dynamics of brain health. BRAINFRAME promotes a culture of collaboration, focusing on the development of shared, FAIR-compliant protocols and AI-driven analytical pipelines to enhance research reproducibility and global competitiveness. BRAINFRAME acts as a coordination and support framework to bring translational neuroscience at IMR to a new level by partnering with leading European research institutions. The project will implement a comprehensive set of cooperation activities to strengthen scientific and administrative capacities, including structured researcher mobility schemes, cross-border expert training, and AI-governance workshops. By integrating molecular data with human-level neurophysiology, the consortium fosters an environment where researchers can develop advanced digital skills and implement responsible AI solutions. BRAINFRAME will generate substantial scientific and societal impact, reinforcing research careers and ensuring long-term institutional sustainability through open science practices and diverse knowledge-valorisation pathways.

Тип пројекта:

International Projects

Forecasting Depression Trajectories: Early Network-Guided Prediction of Severe and Persistent Disease Courses

Project leader: Dr. Jonathan Repple, Dr. Jovana Bjekić

Project collaborators: Dr. Uroš Konstantinović, Bojana Đukić, Marija Stanković, Milena Spoa, Dragana Stojić, Konstantin Tomić

Duration of the project: 2026-2031.

Leading institution: University of Frankfurt, Institute for Medical Research, University of Belgrade, Charité Berlin, UMC & VUMC Amsterdam, University Paris City, University Heidelberg, University of Melbourne, University of Hanoi

Description of the project:

FUTURE-D aims to redefine early detection and intervention strategies for individuals at risk of severe and persistent depression, positioning the Institute for Medical Research (IMR) as a leading hub within a prestigious international consortium. Moving beyond traditional symptom-based reaction, the project adopts a mechanism-informed prevention framework grounded in network science, dynamical systems, and control theory. Within this innovative program, IMR leads the delivery of precision TMS intervention for depression, utilizing advanced network control theory to calculate individualized, patient-specific stimulation targets. This approach shifts clinical practice from “one-target-fits-all” protocols to high-precision therapy that steers maladaptive brain connectivity back toward resilient configurations.

FUTURE-D serves as a crucial coordination and support tool for IMR to elevate its translational mental health research by partnering with leading global institutions across Germany, the Netherlands, France, and Australia. The project will facilitate the creation of scalable clinical decision-support tools and standardized neurostimulation workflows through a comprehensive set of cooperation activities, including structured mobility, expert training workshops, and intensive capacity-building boot-camps. These efforts will have a substantial scientific, technological, and societal impact, establishing a unique and equitable blueprint for implementing precision psychiatry within resource-constrained settings. To realize the project’s full potential, a wide array of communication, dissemination, and open-science measures will be implemented, ensuring long-term sustainability and policy translation in mental healthcare.

Тип пројекта:

International Projects

Twinning for Excellence in Non-Invasive Brain Stimulation in the Western Balkans

Project leader: Dr. Saša R. Filipović, Dr. Jovana Bjekić

Project collaborators: Dr. Marko Živanović, Dr. Uroš Konstantinović, Dunja Paunović, Katarina Vulić, Marija Stanković, Jasmina Vuksanović, Milan Jelić, Milena Spoa, Dagana Stojić, Kontantin Tomić, Bojana Đukć

Project number: 101059369

Duration of the project: 2022-2025.

Leading institution: Institute for Medical Research, University of Belgrade

Description of the project:

TWINNIBS aims to strengthen the Institute for Medical Research – IMR’s research and innovation (R&I) as well as research management and administration capacities and to develop it into a prospective leading partner in international consortia that can attract strategic investments and R&I funding. TWINNIBS will promote interest in neuroscience research in Serbia and the region, and help to advance it, focusing on the multidisciplinary field of non-invasive brain stimulation (NIBS). NIBS is a set of techniques for transcranial (non-invasive) modulation of the activity in the specific brain areas and the large-scale brain networks to which they contribute. This is an innovative approach to neuroscience research and, ultimately, clinical treatment of a wide spectrum of neuropsychiatric conditions. TWNINIBS will be a coordination and support tool for IMR to bring NIBS research in Serbia to a new level by partnering with leading European R&I institutions from Denmark, Italy, Germany and Austria. TWNNIBS will include a comprehensive set of cooperation and coordination activities to strengthen the scientific and technological capacities of IMR, including short term mobility, virtual and in-person short term expert visits, workshops and boot-camps. A series of collaborative small-scale projects will be conducted with the personalisation of NIBS as an overarching theme. TWINNIBS will strengthen the IMR research management and administration capacities and foster organizational changes. The Centre for NIBS as well as R&I Project Management Unit will be established within the IMR. TWINNIBS will have a substantial scientific, economic/technological, and societal impact towards outcomes specified in this topic as well as a long-term impact on the R&I in the European space, with a special focus on the Western Balkans region. To realise the full potential of the TWINNIBS project a comprehensive set of communication, dissemination, and exploitation measures will be implemented.

Тип пројекта:

International Projects