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European micronutrients recommendation aligned

Project leader:

dr Mirjana Gurinovic

Project collaborators:

Marija Takić, Jasmina Martačić-Debeljak, Tamara Popović, Mirjana Gurinović, Marija Glibetić

Project number: 513944

Duration of the project: January 2005.-June 2010.

Leading Institution:

INSTITUTE OF FOOD RESEARCH Adresse Norwich Research Park, Colney Norwich United Kingdom

Description of the project:

Тип пројекта:

International Projects

Importance of wild canids as hosts and reservoirs for ticks and tick-borne pathogens in Austria and Serbia

Project leader : Dr Snežana Tomanović and Dr Georg Duscher

Project collaborators:

Dr Snežana Tomanović, Dr Darko Mihaljica i Dr Ratko Sukara

Project number:

Duration of the project: 2016-2017

Leading Institution:

Institute for Medical Research, University of Belgrade

Description of the project:

Identification of ticks and tick-borne diseases, as a growing problem in last decades, coincides with the increase of anthropogenic influence on biotic and abiotic components of ecosystems. As a result of direct and indirect anthropogenic impact, the migration of these pathogens to new areas is enabled. Wild canids are important hosts of ixodid ticks and recently they have been recognized as potential reservoirs of several tick-borne pathogens of zoonotic and domestic animals importance. The species like red foxes (Vulpes vulpes) and golden jackals (Canis aureus) also represent an important source of infections for domestic animals and humans, mostly due to their close proximity to human settlements and frequent exposure to different vector species. Currently, these populations are both still rapidly growing in urban areas and spreading their ranges toward Central and Eastern Europe increasing the risk of human and animal exposure to pathogens. However, many aspects of the epidemiology of tick-borne diseases in wild canids, such as host range, tick range and their geographical distribution are still poorly understood.

Тип пројекта:

International Projects

Enzootic transmission cycles of pathogenic microorganisms transmitted by ticks

Project leader: Dr Snežana Tomanović

Project collaborators:

Dr Snežana Tomanović, Dr Darko Mihaljica, Dr Ratko Sukara, Dr Gorana Veinović, i Dr Dragana Marković

Project number: OI173006

Duration of the project: 2011-2019

Leading Institution: Institute for Medical Research, University of Belgrade

Description of the project:

In Europe, at least 6 agents of zoonotic vector-borne diseases have been identified in which ticks play an important role in transmission (Rickettsia sp., Anaplasma phagocytophilum, Borrelia burgdorferi sensu lato, Francisella tularensis, Crimean-Congo hemorrhagic fever virus, tick-borne encephalitis virus). Our preliminary investigations indicate the presence of A. phagocytophilum, F. tularensis, Rickettsia sp. and five genospecies of the B. burgdorferi complex in ixodid ticks in Serbia. According to epidemiological data, tick-borne encephalitis and Crimean-Congo hemorrhagic fever viruses are present in natural foci on the territory of Serbia, but no systematic studies on their presence in ticks have been performed so far. Research in this project included regular collection of material (ticks from vegetation and hosts, serum samples and host tissues), molecular detection of pathogens in samples, and cultivation, characterization and genotyping of these microorganisms. The research focused on potential natural hosts of these zoonotic diseases. The research results provided a clearer picture of the distribution, genetic diversity, and pathogenic potential of tick-borne microorganisms.

Тип пројекта:

National Projects

Toxoplasmosis in HSC transplant recipients: how to improve prevention at a reasonable cost?

Project leader : from the Serbian side: Dr. Olgica Đurković-Đaković, from the French side: Prof. Florence Robert-Gangneux

Project collaborators:

dr Tijana Štajner, dr Jelena Srbljanović, Neda Bauman, Aleksandra Uzelac

Project number:

Duration of the project: January 2018 – December 2019

Leading Institution:

Description of the project:

Diagnosis and monitoring of reactivated toxoplasmosis (RT) in HSCT recipients was introduced into the transplantation practice in Serbia in 2013 (cooperation of the Mother and Child Health Care Institute and the NRL for toxoplasmosis). Despite its many benefits, clinical experience with this approach to control T. gondii infection in HSCT patients has also revealed gaps including diagnostic challenges pertinent for decisions on treatment, and lack of consensus on the frequency and duration of blood sample monitoring by qPCR after HSCT, respective of clinical setting and administration of prophylaxis. Thus, the goal of the proposed project is to, after standardization and harmonization of the qPCR protocol in both partner laboratories, identify subgroups of patients (according to the clinical setting, type of prophylaxis etc.) at the highest risk of RT, that would benefit the most from systematic PCR monitoring, with the final outcome to devise a cost-effective alternative for the prevention of RT after HSCT.

Тип пројекта:

International Projects

Determination of the mutational landscape and clonal architecture and its application in angiogenesis and thrombosis of MPN patients

Project leader : Радек Скода

Project collaborators: Coordinator from Serbia Vladan Čokić, participant Dragana Marković

Project number: IZ73Z0_152420/1

Duration of the project: 2014-2016

Leading Institution: Department of Biomedicine, University of Basel and University Hospital Basel, Switzerland

Description of the project:

We will enter later

Тип пројекта:

International Projects

The interaction of p53 and Wnt-signaling in the stemness of mesenchymal stem cells

Project leader: Dr Jelena Krstić

Project collaborators:

Dr Trivanović Drenka, dr Obradović Hristina, dr Kukolj Tamara, dr Okić-Đorđević Ivana

Project number: 451-03-01039/2015-09/31

Duration of the project: 2016 – 2017

Leading Institution: N/A

Description of the project:

Self-renewal and differentiation of stem cells are finely controlled processes that contribute to the maintenance of tissue homeostasis. Transcription factor p53 has been known to regulate these processes in embryonic and adult stem cells in a dual way via the Wnt signaling pathway. Within this project, the role of p53 and Wnt signaling in the regulation of self-renewal and differentiation of mesenchymal stem cells of perinatal tissues (umbilical cord and amnion) was investigated by analyzing the expression of pluripotency markers (Nanog, Sox2, Oct4) and markers of adipogenic/osteogenic differentiation potential (PPARγ, adiponectin, Runx2, osteocalcin) under the conditions of induced or suppressed p53 expression. This was achieved by different gene transfection approaches, as well as the use of specific pharmacological activators/inhibitors (nutlin, pifithrin).

Тип пројекта:

International Projects

Human culture-expanded adipose stromal/stem cells: serial expansion and maintenance of their proliferative, multipotential and regulatory properties

Води : Dr Jauković Aleksandra

Сарадници на пројекту: Dr Bugarski Diana, dr Kocić Jelena, dr Trivanović Drenka

Број пројекта: 451-03-02338/2012-14/05

Трајање пројекта: 2013 – 2014

Водећа институција:

Опис пројекта:

The use of stem/stromal cells derived from adipose tissue as an autologous source of various differentiated cells has great potential for application in regenerative medicine. This project aimed to define effective methods of multipotent stem/stromal cell extraction from adipose tissue (ASC), their expansion and differentiation ex vivo, as well as the examination of their survival and proliferation upon cryopreservation. In addition, the characteristics of ASCs propagated ex vivo were compared in different cell culture model systems, including cultivation in bioreactors and 3D tissue cultures on biomaterial scaffolds. Also, the important aim of this project included investigations of ASCs effects on the proliferation of various tumor cell lines with special emphasis on the maintenance of ASCs biological characteristics and immunoregulatory properties during long-term culture expansion procedures in order to confirm the safety of their clinical use.

Тип пројекта:

International Projects

Building an open European Network on OsteoArthritis research

Project leader : Corne Baatenburg de Jong

Project collaborators: Drenka Trivanović

Project number: CA21110

Duration of the project: October 2022 – October 2026

Leading Institution: Stichting ReumaNederland, Amsterdam, Holandija

Description of the project:

The main aim of NetwOArk is to set up the European Society for Osteoarthritis (ESOA), with three major stakeholder groups, 1) patients, 2) clinicians and 3) researchers, both from academia and industry. The COST Action will allow us to start the process of building such a European Society, with the aim of coordinating and stimulating more interdisciplinary and transdisciplinary research, technological development and translation of the results to the clinic, aimed at improving the quality of life of those affected by osteoarthritis in Europe. The areas to be addressed in this Action are Primary prevention, Diagnostics, Treatment, Interaction (comorbidities) and Care Management. EU-netwOArk aims to boost new scientific breakthroughs on the five main osteoarthritis themes.

Тип пројекта:

Cost

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