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In Vitro Total Cell Guidance and Fitness

Project leader: Dr. Tiziana Brevini

Project collaborators: Dr. Aleksandra Jauković (MC member), Dr. Drenka Trivanović (MC substitute), Dr. Tamara Kukolj, Dr. Hristina Obradović, Dr. Ivana Okić Đorđević

Project number: CA16119

Duration of the project: March 2017-September 2021.

Leading institution: Universita degli studi di Milano, Milano, Italy

Description of the project:

The aim of this COST Action is to refine the present understanding of in vivo micro/macro-environment in order to reproduce in vitro the physiological system in the best possible way: surface topography, substrate stiffness, mechanical stimulation, chemical cues and localized density will be analyzed. This will allow to develop reliable “3D total guidance” in vitro models reducing the number of animals used and allowing a safe translation of the present basic knowledge in cell repair and regeneration from the laboratory bench to the clinical application, with a positive impact on every day’s life patients and general Health costs. Researches in this field are being performed by different groups in the EU, but efforts need to be coordinated in order to avoid duplication, set targets and guidance for future research and to standardize protocols through a large interdisciplinary collaborative EU network. These goals can only be achieved under a COST program.

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Regenerative and Modulatory Potential of Adult Stem Cells

Project leader: Dr. Diana Bugarski

Project collaborators: Dr. Aleksandra Jauković, Dr. Slavko Mojsilović, Dr. Drenka Trivanović, Dr. Ivana Okić Đorđević, Dr. Tamara Kukolj, Dr. Hristina Obradović, Dr. Jelena Krstić, Dr. Juan F. Santibañez, Dr. Sanja Vignjević Petrinović, Dr. Sanja Momčilović, Dr. Irina Maslovarić

Project number: OI 175062

Duration of the project: January 2011-December 2020.

Leading institution: Institute for Medical Research, University of Belgrade

Description of the project:

This project aimed to investigate the cellular and molecular aspects of the biology and function of multipotent adult stem cells, specifically hematopoietic stem cells and mesenchymal stromal cells. At the beginning of the project period, mesenchymal stromal cells were isolated and characterized (phenotypically and functionally) from various tissues of human and animal origin, including bone marrow, adipose tissue, umbilical cord, dental pulp, and periodontal ligament. In the following phase, the role and mode of action of various factors, primarily the inflammatory microenvironment, on the functional properties of adult stem cells were investigated, as well as the interaction of mesenchymal stromal cells with hematopoietic, immune, and tumor cells, with a particular focus on their role in immunoregulation and tumorigenesis. This project resulted in over 60 publications and presentations at scientific conferences (including 35 in JCI-indexed journals).

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National Projects

Application of Low-Temperature Plasmas in Biomedicine, Environmental Control, and Nanotechnologies

Project leader: Dr. Nevena Puač

Project collaborators: Dr. Pavle Milenković, Dr. Slavko Mojsilović

Project number: III 41011

Duration of the project: January 2011-December 2020.

Leading institution: Institute of Physics, University of Belgrade

Description of the project:

This interdisciplinary project aimed to develop a new system of cold atmospheric plasma for use in biomedicine, environmental control, and nanotechnology. It consisted of four sub-projects: 1) Atmospheric discharges, 2) Plasma application in biology and medicine, 3) Plasma application in positron diagnostics, nanotechnology, and material functionalization, and 4) Measurements of biogenic volatile organic compounds. Institute for Medical Research participated in the second sub-project, led by Professor Pavle Milenković. Within this sub-project, the impact of cold atmospheric plasma on the regenerative properties of human dental-derived mesenchymal stromal/stem cells was investigated, both in vitro and in vivo (the rabbit calvarial critical-size defect model). The result of this sub-project was the publication of several papers in prestigious scientific journals and presentations at numerous international conferences.

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National Projects

International Network for Translating Research on Perinatal Derivatives into Therapeutic Approaches

Project leader: Dr. Ornella Parolini

Project collaborators: Dr. Diana Bugarski, Dr. Slavko Mojsilović, Dr. Hristina Obradović

Project number: CA17116

Duration of the project: October 2018-April 2023.

Leading Institution: Università Cattolica del Sacro Cuore, Rome, Italy

Description of the project:

This COST action aims to unite a currently fragmented critical mass of academic, clinical, and industry expertise to improve both the fundamental understanding and translational potential of perinatal derivatives. It includes participants with extensive know-how in basic research, clinical trials, regulatory affairs, and biomedical industry. SPRINT is joining forces to strengthen knowledge in the field and overcome the bottlenecks of translation to enable innovative therapeutic applications of perinatal-derived tissues, cells, and factors. Within Action Working Group 2, the IMR team worked to review preclinical studies in animal models to assess the efficacy of therapeutic interventions and identify research gaps, resulting in three papers co-authored by IMR team members.

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