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Importance of wild canids as hosts and reservoirs for ticks and tick-borne pathogens in Austria and Serbia

Project leader: Dr Snežana Tomanović and Dr Georg Duscher

Project collaborators: Dr Snežana Tomanović, Dr Darko Mihaljica and Dr Ratko Sukara

Project number:

Duration of the project: 2016-2017

Leading Institution:Institute for Medical Research, University of Belgrade

Description of the project:

Identification of ticks and tick-borne diseases, as a growing problem in last decades, coincides with the increase of anthropogenic influence on biotic and abiotic components of ecosystems. As a result of direct and indirect anthropogenic impact, the migration of these pathogens to new areas is enabled. Wild canids are important hosts of ixodid ticks and recently they have been recognized as potential reservoirs of several tick-borne pathogens of zoonotic and domestic animals importance. The species like red foxes (Vulpes vulpes) and golden jackals (Canis aureus) also represent an important source of infections for domestic animals and humans, mostly due to their close proximity to human settlements and frequent exposure to different vector species. Currently, these populations are both still rapidly growing in urban areas and spreading their ranges toward Central and Eastern Europe increasing the risk of human and animal exposure to pathogens. However, many aspects of the epidemiology of tick-borne diseases in wild canids, such as host range, tick range and their geographical distribution are still poorly understood.

Тип пројекта:

International Projects

Toxoplasmosis in HSC transplant recipients: how to improve prevention at a reasonable cost?

Project leader:

from the Serbian side: Dr. Olgica Đurković-Đaković, from the French side: Prof. Florence Robert-Gangneux

Project collaborators:

dr Tijana Štajner, dr Jelena Srbljanović, Neda Bauman, Aleksandra Uzelac

Project number: /

Duration of the project: January 2018 – December 2019

Leading Institution: /

Description of the project:

Diagnosis and monitoring of reactivated toxoplasmosis (RT) in HSCT recipients was introduced into the transplantation practice in Serbia in 2013 (cooperation of the Mother and Child Health Care Institute and the NRL for toxoplasmosis). Despite its many benefits, clinical experience with this approach to control T. gondii infection in HSCT patients has also revealed gaps including diagnostic challenges pertinent for decisions on treatment, and lack of consensus on the frequency and duration of blood sample monitoring by qPCR after HSCT, respective of clinical setting and administration of prophylaxis. Thus, the goal of the proposed project is to, after standardization and harmonization of the qPCR protocol in both partner laboratories, identify subgroups of patients (according to the clinical setting, type of prophylaxis etc.) at the highest risk of RT, that would benefit the most from systematic PCR monitoring, with the final outcome to devise a cost-effective alternative for the prevention of RT after HSCT.

Тип пројекта:

International Projects

Determination of the mutational landscape and clonal architecture and its application in angiogenesis and thrombosis of MPN patients

Project leader :Radek Skoda

Project collaborators:

Coordinator from Serbia Vladan Čokić, participant Dragana Marković

Project number: IZ73Z0_152420/1

Duration of the project: 2014-2016

Leading Institution: Department of Biomedicine, University of Basel and University Hospital Basel, Switzerland

Description of the project:

We will enter later

Тип пројекта:

International Projects

Reviewing prevention measures and evaluating the burden of toxoplasmosis in transplant patients in European countries

Project leader : dr Florence ROBERT-GANGNEUX,

Project collaborators:

Olgica Đurković Đaković, PhD, Tijana Štajner, PhD

Project number: grant (P307-09) from ESCMID

Duration of the project: 2014 – 2016.

Leading Institution:

University of Rennes, CHU Rennes, France

Опис пројекта:

The number of transplants is increasing, leading to an increasing number of patients at risk of toxoplasmosis. Toxoplasmosis prevention practice, prevalence, and outcomes for hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT; heart, kidney, or liver) patients in Europe were analyzed. Electronic data on the transplant population and prevention guidelines/regulations and clinical data on toxoplasmosis cases diagnosed during 2010–2014 were collected. Serological pre-transplant screening of allohematopoietic stem cell donors was performed in 80% of countries, screening of organ donors in 100%. Recipients were systematically screened in 6 countries. Targeted chemoprophylaxis against toxoplasma was heterogeneous. A total of 87 cases of toxoplasmosis were recorded (58 allo-HSCT, 29 SOT). The 6-month survival rate was lower among Toxoplasma seropositive recipients and among allohematopoietic stem cell and liver recipients. Chemoprophylaxis improved outcomes for SOT recipients. Toxoplasmosis continues to be associated with high mortality rates among transplant recipients. Guidelines are urgently needed to standardize prophylactic regimens and optimize patient management.

Тип пројекта:

International Projects

Fatty acid profile and trans fatty acid content in composition databases food in traditional food as a guideline towards a healthier choice of our food population

Project leader:Danijela Ristić-Medić

Project collaborators:

Danijela Ristić-Medić, Snježana Petrović, Aleksandra Arsić, Marija Takić , Vesna Vučić , Milica ZekovićMirjana Gurinović

Project number: 451-03- 3095/2014-09/56

Duration of the project:January 2014-December 2015

Leading Institution:

Center of Excellence for Nutrition and Metabolism, Institute for Medical Research, University of Belgrade

Description of the project:

The project focused on trans fatty acids (TFA) content, especially in traditional food in Serbia and Slovenia, and the assessment of TFA dietary intake. The primary goal of the project was promoting general health, because there are convincing data that TFA intake is associated with an increased risk of cardiovascular diseases. Teamwork, training, and mutual visits contributed to connecting young scientists with the aim of knowledge transfer. Determination of TFA by analytical methods, standardization of portion sizes, and application of software contributed to the harmonization of dietary intake assessment in both countries. Selection of foods and complex dishes with higher TMK content, recommendations, and constant media education can have a beneficial health effect on our population. The results of the project were published in an international journal doi:10.21101/cejph.a5928 and presented at international meetings.

Тип пројекта:

International Projects

Effect of dietary lipids on cardiovascular parameters, lipogenesis and antioxidant status in hypertensive rats

Project leader :Dr Jelica Grujić Milanović

Project collaborators:

Dr Jelica Grujić Milanović, Dr Nevena Mihailović-Stanojević, dr Danijela Karanović

Project number: 337-00-205/2019-09/32

Duration of the project: 2019-2022

Leading Institution:

University of Belgrade, Institute for Medical Research, Institute of national importance for the Republic of Serbia

Description of the project:

The main objective of this project was to determine the mechanism of action of high-fat foods of different origins (animal/plant) and the possibility of preventing the metabolic syndrome by modulating the n6/n3 ratio of dietary fats on the oxidative status and expression of various transcription factors that are part of the blood pressure regulatory system. The reason for this approach lies in the general public health interest in developing new strategies for the prevention and treatment of the metabolic syndrome and, consequently, of cardiovascular diseases, with the aim of reducing the number of people affected. Therefore, the aim of this project was to study the effects of a diet containing vegetable/animal fats with different ratios of n6/n3 lipids on the cardiovascular system and lipogenesis in different tissues under both physiological and pathological conditions.

Тип пројекта:

International Projects

Cardiac remodelling down the calmodulin kinase 2 cascade

Project leader:Dr Milan Ivanov

Project collaborators:

Dr Milan Ivanov, dr Zoran Miloradović, dr Nevena Mihailović-Stanojević, dr Đurđica Jovović, dr Una-Jovana Vajić, dr Danijela Karanović

Project number: 451-03-02141/2017-09/44

Duration of the project: 2018-2020

Leading Institution:

University of Belgrade, Institute for Medical Research, Institute of national importance for the Republic of Serbia

Description of the project:

The main objective of this project was to characterize the spatial and temporal activation of signaling pathways for Ca2+/CaM/CaMKIIδC- and δB-kinases in defined subcellular areas of isolated adult ventricular cardiomyocytes and their influence on the initiation and progression of hypertrophy and heart failure. The project was performed on isolated rat cardiomyocytes and healthy and diseased human cardiomyocytes. This project enabled multidisciplinary collaboration of biologists, molecular biologists, biotechnologists and physicians from Austria and Serbia, which in the future will serve as a basis for the creation of a network of institutions for the development of modern approaches in experimental cardiovascular physiology. Complementarity of methods as well as scientific work and topics under in vivo and in vitro conditions of scientists from Austria and Serbia resulted in improvement of approach to solving problems in the field of cardiovascular physiology.

Тип пројекта:

International Projects

The role of nitric oxide, free radicals and Ang2 peptide on vascular structure and function in experimental hypertension.

Project leader :Dr Zoran Miloradović

Project collaborators:

Dr Zoran Miloradović, dr Đurđica Jovović, dr Nevena Mihailović-Stanojević, dr Jelica Grujić Milanović

Project number: СК-СРБ-0026-29

Duration of the project: 2010-2011.

Leading Institution:

University of Belgrade, Institute for Medical Research, Institute of national importance for the Republic of Serbia

Description of the project:

A chronic decrease in nitric oxide synthesis caused by blockade of the enzyme constitutive nitric oxide synthase results in a permanent increase in blood pressure associated with hypertrophy of the heart and arterial blood vessels. The aim of the study was to investigate the comparative effects of nitric oxide synthase inhibitors associated with vascular and cardiac changes. The long-term effects of the combined action of two types of nitric oxide synthase inhibitors on the heart and on the structure and function of blood vessels, as well as their effects on the cellular and extracellular components of the walls of conducting blood vessels in terms of the role of free radicals and the renin-angiotensin system, were investigated. The results obtained represent a contribution to the understanding of the basic regulatory mechanisms in hypertension and to the development of new approaches for the prevention and therapy of this disease.

Тип пројекта:

International Projects

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