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The pathogenetic mechanisms in hematological malignancies

Project leader :Vladan Čokić

Project collaborators:

Dragana Marković, Marijana Kovačić

Project number: ОI175053

Duration of the project: 2011-2019

Leading Institution:

Institute for Medical Research, University of Belgrade

Description of the project:

We will enter later

Тип пројекта:

National Projects

Novel encapsulation and enzyme technologies for designing of new biocatalysts and biologically active compounds targeting enhancement of food quality, safety and competitiveness

Project leader:Branko Bugarski

Project collaborators:

Vesna Ilić, Ivana Drvenica

Project number: III46010

Duration of the project: 2011-2019

Leading Institution:

Faculty of Technology and Metallurgy, University of Belgrade

Description of the project:

We will enter later

Тип пројекта:

National Projects

Control of infections by apicomplexan pathogens: from new sites of drug action to prediction

Project leader :Olgica Đurkovi-Đaković, PhD,

Project collaborators:

Dr sci Nikolić Aleksandra, Dr sci nBobić Branko, Dr sci Štajner Tijana , Dr sci Jelena Srbljanović, Dr sci Vitomir Đokić Dr sci Vladimir Ivović, Dr sci Marija Vujanić, Dr sci Ksenija Slavić, Dr sci Irena Rajnprecht, Dr Neda Bauman

Project number: III 41019

Duration of the project: 2011-2019

Leading Institution:

Institute for Medical Research, University of Belgrade

Description of the project:

The goal of this multidisciplinary project, which integrates basic, applied and developmental research on infections caused by leading apicomplex pathogens, is to improve the control of toxoplasmosis and malaria, by improving therapeutic options and developing strategies for the prevention of infection, which will contribute to the improvement of control both at the clinical level and at the level public health. The scientific importance of the planned results lies in the contribution to the knowledge of the pathogenesis of malaria and toxoplasmosis. Basic research on the metabolic processes and transport molecules involved in these contribute to the understanding of the complex relationship established between the parasite and the host, and indicate potential sites of action of future drugs. The development of new transgenic lines as well as their characterization will increase the arsenal of tools available for the identification of further therapeutics. The synthesis of new active substances and eventual identification of those with activity against P. falciparum and T. gondii will represent in itself a contribution to the repertoire of chemotherapeutics, with enormous development potential. Applied research has immediate clinical significance. The introduction of new diagnostic methods (such as molecular diagnostics of malaria) will represent a contribution to the clinical care of these patients in Serbia. Also, in the same sense, knowledge of the genetic variability of T. gondii and P. falciparum strains that are isolated in Serbia will be useful because it will contribute to treatment with a more adequate choice of drugs, but it will also have wider significance because they contribute to knowledge of the molecular map of these organisms at the level of the region, Europe and the world.

Тип пројекта:

National Projects

Regenerative and modulatory potential of adult stem cells

Project leader :Diana Bugarski

Project collaborators:

Vesna Ilić, Irina Maslovarić

Project number: OI175062

Duration of the project: 2011-2019

Leading Institution:

Institute for Medical Research, University of Belgrade

Description of the project:

We will enter later

Тип пројекта:

National Projects

Reviewing prevention measures and evaluating the burden of toxoplasmosis in transplant patients in European countries

Project leader : dr Florence ROBERT-GANGNEUX,

Project collaborators:

Olgica Đurković Đaković, PhD, Tijana Štajner, PhD

Project number: grant (P307-09) from ESCMID

Duration of the project: 2014 – 2016.

Leading Institution:

University of Rennes, CHU Rennes, France

Опис пројекта:

The number of transplants is increasing, leading to an increasing number of patients at risk of toxoplasmosis. Toxoplasmosis prevention practice, prevalence, and outcomes for hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT; heart, kidney, or liver) patients in Europe were analyzed. Electronic data on the transplant population and prevention guidelines/regulations and clinical data on toxoplasmosis cases diagnosed during 2010–2014 were collected. Serological pre-transplant screening of allohematopoietic stem cell donors was performed in 80% of countries, screening of organ donors in 100%. Recipients were systematically screened in 6 countries. Targeted chemoprophylaxis against toxoplasma was heterogeneous. A total of 87 cases of toxoplasmosis were recorded (58 allo-HSCT, 29 SOT). The 6-month survival rate was lower among Toxoplasma seropositive recipients and among allohematopoietic stem cell and liver recipients. Chemoprophylaxis improved outcomes for SOT recipients. Toxoplasmosis continues to be associated with high mortality rates among transplant recipients. Guidelines are urgently needed to standardize prophylactic regimens and optimize patient management.

Тип пројекта:

International Projects

Fatty acid profile and trans fatty acid content in composition databases food in traditional food as a guideline towards a healthier choice of our food population

Project leader:Danijela Ristić-Medić

Project collaborators:

Danijela Ristić-Medić, Snježana Petrović, Aleksandra Arsić, Marija Takić , Vesna Vučić , Milica ZekovićMirjana Gurinović

Project number: 451-03- 3095/2014-09/56

Duration of the project:January 2014-December 2015

Leading Institution:

Center of Excellence for Nutrition and Metabolism, Institute for Medical Research, University of Belgrade

Description of the project:

The project focused on trans fatty acids (TFA) content, especially in traditional food in Serbia and Slovenia, and the assessment of TFA dietary intake. The primary goal of the project was promoting general health, because there are convincing data that TFA intake is associated with an increased risk of cardiovascular diseases. Teamwork, training, and mutual visits contributed to connecting young scientists with the aim of knowledge transfer. Determination of TFA by analytical methods, standardization of portion sizes, and application of software contributed to the harmonization of dietary intake assessment in both countries. Selection of foods and complex dishes with higher TMK content, recommendations, and constant media education can have a beneficial health effect on our population. The results of the project were published in an international journal doi:10.21101/cejph.a5928 and presented at international meetings.

Тип пројекта:

International Projects

Synthesis of aminoquinolines and their derivatives as antimalarials and botulinum neurotoxin inhibitors

Project leader :Academician Bogdan Šolaja, Ph.D.,

Project collaborators:

Olgica Đurković Đaković, PhD

Project number: OI 172008

Duration of the project: 2011.-2019.

Leading Institution:

Faculty of Chemistry, University of Belgrade

Description of the project:

Objective: to replace the antimalarial chloroquine (CQ) due to the increase in the number of MDR P.falciparum strains; to develop new tetraoxane antimalarials due to the appearance of significantly reduced clinical efficacy of drugs containing artemisinin derivatives (Nat.Rev.Microbiol 2010,8,272); transform leading non-toxic inhibitors (SMNPIs) of BoNT/A LC into bioavailable inhibitors (low nM region) that will become drug candidates. To develop compounds that could treat botulism caused by botulinum neurotoxin poisoning. The project includes the development of dual inhibitors, antimalarial compounds and botulinum neurotoxin inhibitors. SMNPIs based on the structure of diazachrysene, cholic acid and adamantane have been shown to inhibit CQR P.f. strains with IC50<10nM, as well as to treat mice at doses of 50-80mg/kg/day without toxic effects after necropsy. Another antimalarial, an aminoquinoline steroid derivative, also proved to be a strong BoNT inhibitor: BoNT/A LC IC50=2.20µM;Ki=3.20µM. The project includes the synthesis of new chemotypes and the optimization of current leads discovered by us; potential in vivo candidates will be tested for metabolic stability in liver microsomes. We will apply the methods of modern computational chemistry, the simulation of the behavior of interacting molecules and the calculation of images of the electrostatic potentials of these compounds in different pH environments, applying higher degrees of theory. Scientific collaborations with WRAIR (malaria), USAMRIID (BoNT inhibition), and SAIC-NCI (computational modeling; CRADA contracts and/or joint scientific projects).

Тип пројекта:

National Projects

European network for foodborne parasites

Project leader:: Prof Lucy Robertson

Project collaborators:

Olgica Đurković-Đaković, Ph.D., Aleksandra Nikolić, Ph.D., Branko Bobić, Ph.D., Ivana Klun, Ph.D., Aleksandra Uzelac, Ph.D., Vladimir Ćirković, Ph.D.

Project number: FA1408

Duration of the project: 2015 – 2019.

ВLeading Institution:

Norwegian University of Life Sciences (NMBU). Faculty of Veterinary Medicine Department of Paraclinical Sciences (PARAFAG) Parasitology Norway

Description of the project:

The COST Action FA1408, A European Network for Foodborne Parasites (Euro-FBP) aims to combat the impact of FBP on public health by facilitating the multidisciplinary cooperation and partnership between groups of researchers and between researchers and stakeholders.

Тип пројекта:

Cost

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