International Projects Archives - Page 4 of 4 - Institute for Medical Research

Reviewing prevention measures and evaluating the burden of toxoplasmosis in transplant patients in European countries

Project leader : dr Florence ROBERT-GANGNEUX,

Project collaborators:

Olgica Đurković Đaković, PhD, Tijana Štajner, PhD

Project number: grant (P307-09) from ESCMID

Duration of the project: 2014 – 2016.

Leading Institution:

University of Rennes, CHU Rennes, France

Опис пројекта:

The number of transplants is increasing, leading to an increasing number of patients at risk of toxoplasmosis. Toxoplasmosis prevention practice, prevalence, and outcomes for hematopoietic stem cell transplant (HSCT) and solid organ transplant (SOT; heart, kidney, or liver) patients in Europe were analyzed. Electronic data on the transplant population and prevention guidelines/regulations and clinical data on toxoplasmosis cases diagnosed during 2010–2014 were collected. Serological pre-transplant screening of allohematopoietic stem cell donors was performed in 80% of countries, screening of organ donors in 100%. Recipients were systematically screened in 6 countries. Targeted chemoprophylaxis against toxoplasma was heterogeneous. A total of 87 cases of toxoplasmosis were recorded (58 allo-HSCT, 29 SOT). The 6-month survival rate was lower among Toxoplasma seropositive recipients and among allohematopoietic stem cell and liver recipients. Chemoprophylaxis improved outcomes for SOT recipients. Toxoplasmosis continues to be associated with high mortality rates among transplant recipients. Guidelines are urgently needed to standardize prophylactic regimens and optimize patient management.

Тип пројекта:

International Projects

Fatty acid profile and trans fatty acid content in composition databases food in traditional food as a guideline towards a healthier choice of our food population

Project leader:Danijela Ristić-Medić

Project collaborators:

Danijela Ristić-Medić, Snježana Petrović, Aleksandra Arsić, Marija Takić , Vesna Vučić , Milica ZekovićMirjana Gurinović

Project number: 451-03- 3095/2014-09/56

Duration of the project:January 2014-December 2015

Leading Institution:

Center of Excellence for Nutrition and Metabolism, Institute for Medical Research, University of Belgrade

Description of the project:

The project focused on trans fatty acids (TFA) content, especially in traditional food in Serbia and Slovenia, and the assessment of TFA dietary intake. The primary goal of the project was promoting general health, because there are convincing data that TFA intake is associated with an increased risk of cardiovascular diseases. Teamwork, training, and mutual visits contributed to connecting young scientists with the aim of knowledge transfer. Determination of TFA by analytical methods, standardization of portion sizes, and application of software contributed to the harmonization of dietary intake assessment in both countries. Selection of foods and complex dishes with higher TMK content, recommendations, and constant media education can have a beneficial health effect on our population. The results of the project were published in an international journal doi:10.21101/cejph.a5928 and presented at international meetings.

Тип пројекта:

International Projects

Effect of dietary lipids on cardiovascular parameters, lipogenesis and antioxidant status in hypertensive rats

Project leader :Dr Jelica Grujić Milanović

Project collaborators:

Dr Jelica Grujić Milanović, Dr Nevena Mihailović-Stanojević, dr Danijela Karanović

Project number: 337-00-205/2019-09/32

Duration of the project: 2019-2022

Leading Institution:

University of Belgrade, Institute for Medical Research, Institute of national importance for the Republic of Serbia

Description of the project:

The main objective of this project was to determine the mechanism of action of high-fat foods of different origins (animal/plant) and the possibility of preventing the metabolic syndrome by modulating the n6/n3 ratio of dietary fats on the oxidative status and expression of various transcription factors that are part of the blood pressure regulatory system. The reason for this approach lies in the general public health interest in developing new strategies for the prevention and treatment of the metabolic syndrome and, consequently, of cardiovascular diseases, with the aim of reducing the number of people affected. Therefore, the aim of this project was to study the effects of a diet containing vegetable/animal fats with different ratios of n6/n3 lipids on the cardiovascular system and lipogenesis in different tissues under both physiological and pathological conditions.

Тип пројекта:

International Projects

Cardiac remodelling down the calmodulin kinase 2 cascade

Project leader:Dr Milan Ivanov

Project collaborators:

Dr Milan Ivanov, dr Zoran Miloradović, dr Nevena Mihailović-Stanojević, dr Đurđica Jovović, dr Una-Jovana Vajić, dr Danijela Karanović

Project number: 451-03-02141/2017-09/44

Duration of the project: 2018-2020

Leading Institution:

University of Belgrade, Institute for Medical Research, Institute of national importance for the Republic of Serbia

Description of the project:

The main objective of this project was to characterize the spatial and temporal activation of signaling pathways for Ca2+/CaM/CaMKIIδC- and δB-kinases in defined subcellular areas of isolated adult ventricular cardiomyocytes and their influence on the initiation and progression of hypertrophy and heart failure. The project was performed on isolated rat cardiomyocytes and healthy and diseased human cardiomyocytes. This project enabled multidisciplinary collaboration of biologists, molecular biologists, biotechnologists and physicians from Austria and Serbia, which in the future will serve as a basis for the creation of a network of institutions for the development of modern approaches in experimental cardiovascular physiology. Complementarity of methods as well as scientific work and topics under in vivo and in vitro conditions of scientists from Austria and Serbia resulted in improvement of approach to solving problems in the field of cardiovascular physiology.

Тип пројекта:

International Projects

The role of nitric oxide, free radicals and Ang2 peptide on vascular structure and function in experimental hypertension.

Project leader :Dr Zoran Miloradović

Project collaborators:

Dr Zoran Miloradović, dr Đurđica Jovović, dr Nevena Mihailović-Stanojević, dr Jelica Grujić Milanović

Project number: СК-СРБ-0026-29

Duration of the project: 2010-2011.

Leading Institution:

University of Belgrade, Institute for Medical Research, Institute of national importance for the Republic of Serbia

Description of the project:

A chronic decrease in nitric oxide synthesis caused by blockade of the enzyme constitutive nitric oxide synthase results in a permanent increase in blood pressure associated with hypertrophy of the heart and arterial blood vessels. The aim of the study was to investigate the comparative effects of nitric oxide synthase inhibitors associated with vascular and cardiac changes. The long-term effects of the combined action of two types of nitric oxide synthase inhibitors on the heart and on the structure and function of blood vessels, as well as their effects on the cellular and extracellular components of the walls of conducting blood vessels in terms of the role of free radicals and the renin-angiotensin system, were investigated. The results obtained represent a contribution to the understanding of the basic regulatory mechanisms in hypertension and to the development of new approaches for the prevention and therapy of this disease.

Тип пројекта:

International Projects

Synergistic education of parents with children with special needs

Lead: Dr Tatjana Zorčec

Collaborators on the Project: Vesna Vučić, Danijela Ristić-Medić

Scientific research groups: Group for Nutritional Biochemistry and Dietology, Center of Exceptional Value for Nutrition and Metabolism

Project number: KA220-ADU-AB287E78
Duration: December 2022 – November 2024,

Leading Institution: Macedonian Association for Applied Psychology-MAAP, North Macedonia Hrvatsko katolicko sveuciliste, Croatia Institut za medicinska istrazivanja, Serbia

Description:

The project aims to empower parents of children with special needs in everyday life, improve their parenting skills and social inclusion, health and quality of life. The objectives are to use an innovative educational approach to improve parental skills in working with children with special needs, with the newly created comprehensive curriculum and training materials and its on-line platform for continuous e-learning, in line with the individual needs and expectations of parents. . The project aims to empower parents of children with special needs in daily life, improve their parental skills and social inclusion, health, and quality of life. Objectives are to use innovative educational approach for improving parenting skills in dealing with children with special needs, with a newly created comprehensive training curriculum and materials and on-line platform of it for continuous e-learning, in line with the parent’s individual needs and expectations.

Тип пројекта:

International Projects

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