Project leader: Dr. Zoran Miloradović

Project collaborators: Dr. Đurđica Jovović, Dr. Nevena Mihailović-Stanojević, Dr. Jelica Grujić Milanović, Dr. Kristek František, Dr. Soňa Čačányiová

Project number: СК-СРБ-0026-29

Duration of the project: 2010-2011.

Leading institution: Institute for Medical Research, University of Belgrade

Collaborating institution: Institute of Normal and Pathological Physiology SAS, Bratislava, Slovakia

Description of the project:

A chronic decrease in nitric oxide synthesis caused by blockade of the enzyme constitutive nitric oxide synthase results in a permanent increase in blood pressure associated with hypertrophy of the heart and arterial blood vessels. The aim of the study was to investigate the comparative effects of nitric oxide synthase inhibitors associated with vascular and cardiac changes. The long-term effects of the combined action of two types of nitric oxide synthase inhibitors on the heart and on the structure and function of blood vessels, as well as their effects on the cellular and extracellular components of the walls of conducting blood vessels in terms of the role of free radicals and the renin-angiotensin system, were investigated. The results obtained represent a contribution to the understanding of the basic regulatory mechanisms in hypertension and to the development of new approaches for the prevention and therapy of this disease.