Myeloid immune cells are important mediators in the pathology of many diseases, especially in diseases associated with chronic inflammation (DACI). Recent advancements in molecular profiling technologies have led to the generation of large data sets, many of those not fully explored yet, but accessible to the entire scientific community via public data repositories. It is the aim of this COST Action to repurpose those data sets, retrieve and curate myeloid cell-specific information, and apply this information to develop novel biomarkers for DACI. To this end, Mye-InfoBank utilise COST networking tools to enable the interaction of molecular biologists, bioinformaticians, immunobiologists, biobank coordinators and clinicians. The concerted activity of these experts on myeloid cell biology (either basic or clinical research), bioinformatics, and bio-banking, will transform complex molecular information into standardised and applicable biomarkers, which have the potential to improve clinical decision making in a number of socio-economically important diseases.