The main objective of this project was to determine the mechanism of action of high-fat foods of different origins (animal/plant) and the possibility of preventing the metabolic syndrome by modulating the n6/n3 ratio of dietary fats on the oxidative status and expression of various transcription factors that are part of the blood pressure regulatory system. The reason for this approach lies in the general public health interest in developing new strategies for the prevention and treatment of the metabolic syndrome and, consequently, of cardiovascular diseases, with the aim of reducing the number of people affected. Therefore, the aim of this project was to study the effects of a diet containing vegetable/animal fats with different ratios of n6/n3 lipids on the cardiovascular system and lipogenesis in different tissues under both physiological and pathological conditions.