Projects

Environmental monitoring of food and waterborne parasites (PARASITE HUNTER)

Project leader: Dr. Ivana Klun

Project collaborators: Dr. Duško Ćirović, Dr. Oliver Tošković, Dr. Aleksandra Penezić, Dr. Stanislav Simin, Dr. Aleksandra Uzelac, Vladimir Ćirković, Dragana Miličić, Nikola Betić, Neda Bogdanović, Ilija Pantelić

Project number: 2424

Duration of the project: 2024-2026.

Leading institution: Institute for Medical Research, University of Belgrade

Collaborating institutions: Faculty of Biology, University of Belgrade, Faculty of Philosophy, University of Belgrade, Faculty of Agriculture, University of Novi Sad, Institute of Meat Hygiene and Technology

Description of the project:

The increasing prevalence of food and waterborne parasitoses in humans and animals in Europe calls for the need for holistic surveillance to detect emerging threats and identify reservoirs of infection, so that public health authorities can be alerted in a timely manner. Systematic monitoring programs for most of the parasites which cause these diseases do not exist and most parasitoses are not notifiable, thus it is upon the scientific community to gather evidence of these silent epidemics, raise awareness and advocate for innovative and improved food safety measures to reduce disease burden.

PARASITE HUNTER aims to incorporate One Health principles in food safety, with a strong emphasis on environmental matrices, as the 21st century is characterized by significantly perturbed ecosystems due to anthropogenic disturbances. The impact of ecosystem health and wildlife on food safety will be evaluated and communication with stakeholders will be established. Standardized parasitological methods [sedimentation, (Mini)FLOTAC] and validated molecular techniques (multiplex qPCR, nested PCR) will be applied to detect, quantify, and assess viability (staining and in vitro culture) of food and waterborne parasites (FWP) of public health significance in various human and animal foods, water and soil in which the food is produced. This project aims to establish a data driven surveillance framework for FWP to improve food safety beyond the current standard by including monitoring of vulnerable groups (humans and animals) not covered by the current food safety legislation. Stakeholders will be engaged through questionnaires to assess the level of awareness regarding FWP and help draft a white paper with proposals to reduce/control the FWP burden. As a result of the project activities, a sustainable, state of the art FWP surveillance program for timely identification of emerging threats to public health, and stakeholder approved measures to improve food safety are expected.

Тип пројекта:

National Projects

Harnessing the potential of underutilized crops to promote sustainable food production (DIVERSICROP)

Project number: CA22146

WG Nutrition leader: Marija Knez

Project collaborator: Jelena Milešević, Petar Jovanović

Duration of the project: October 2023-September2027

Leading institution: University College Dublin, Ireland

 

Description of the project:

With population growing rapidly and within the context of agro-climatic changes, there is an increased demand to sustainably produce nutritious food. In Europe, many nutrient-dense foods are not widely grown and consumed, despite their suitability to European climates and environments, and viability for sustainable production with lower inputs. Underutilised crops that are stress resilient such as rye and legumes, have the potential to supply key nutrients and improve diets and risk of diet-related diseases. Such crops have a long history of cultivation across the continent and are part of the national historic food identity of different European countries yet are underutilised due to several complex reasons. DIVERSICROP addresses these challenges using an innovative, cross-sectoral and multidisciplinary approach by analysing the deep history of underutilised crops in Europe, understanding the genetic diversity and adaptation to climate change of crop germplasm, analysing current regional trends in the consumption of food products and by involving national and EU policymakers and key stakeholders to revive diverse crop production and maximise the impact of Europe’s agricultural sustainability. DIVERSICROP aims to harmonise fragmented data and develop strategies for the sustainable cultivation of target crops, striking a balance between agricultural sustainability and human nutritional value. DIVERSICROP brings together a skilled and interdisciplinary network to identify climate-resilient crop lines, and potential nutritional and health benefits of their consumption to rethink our food systems. DIVERSICROP will strengthen the Farm to Fork and the Biodiversity strategies under the European Green Deal to contribute to achieving the UN Sustainable Development Goals.

Тип пројекта:

Cost

European partnership for a sustainable Future of Food Systems- FutureFoods

Project leader: Jelena Milešević, coordinator for IMR team

Project number: 101136361

Duration of the project: 2024-2026

Leading institution: AGENCE NATIONALE DE LA RECHERCHE (PIC: 998711613, located in PARIS, FR)

Abstract

The vision of FutureFoodS is to collectively achieve environmentally friendly, socially secure, fair and economically viable healthy and safe Food Systems (FS) for Europe. FutureFoodS gather 87 partners from 22 EU Member States, 6 Associated Countries and 1 third country. FutureFoodS includes public and private actors, policy makers, foundations, locally, sub-nationally, nationally, EU-widely. All these FutureFoodS partners are fully aligned on the vision for the Partnership and the methodology for its implementation in line with SDG17 and EU Green Deal components. This vision has been broken down into general (GO), specific (SO) and operational (OO) objectives applying across the 4 R&I areas and 4 transversal activities identified by the FutureFoods consortium in its stable draft Strategic Research and Innovation Agenda (SRIA) which constitutes the strategic backbone of the project. The four GO cover: GO1 – Functioning of FS; GO2 – System approaches; GO3 – Inclusive government; GO4 – Co-creation cases. These GO have then been translated into SO prioritised in line with the timescale and resources of the Partnership: SO1 – Change the way we eat; SO2- Change the way we process and supply food, SO3 – Change the way we connect with FSs and SO4 – Change the way we govern FS. In addition, 6 interconnected OO have been set: OO1- Pooling R&I resources and programming; OO2 – Operational FS Observatory; OO3 – Active FS knowledge Hub of FS Labs; OO4 – Functioning knowledge sharing and scaling mechanisms; OO5- Revisiting the SRIA; OO6 – Promoting, supporting, widening & gathering FS various communities. The objectives implemented in the 8 WPs of FutureFoodS will exert impact directly or indirectly in most of the destinations of Horizon Europe’s Cluster 6 2023-2024 work programme and particularly for the topic destination ‘Fair, healthy and environment-friendly FS from primary production to consumption’ echoing to the main EU and World FS policies & strategies.

Тип пројекта:

HORIZON-RIA

Tackling micronutrient malnutrition and hidden hunger to improve health in the EU- Zero_HiddenHunger_EU

Project leader: Jelena Milešević, coordinator for IMR team

Project collaborators: Marija Knez, Ivana Šarac

Project number: 101137127

Duration of the project: January 2024-December 2028

Leading Institution: UNIVERSITY COLLEGE CORK – NATIONAL UNIVERSITY OF IRELAND, CORK – UCC

Project description

Micronutrient (MN) deficiency is a form of malnutrition that occurs due to low intake and/or absorption of minerals and vitamins, with adverse consequences for human development and health. Children, adolescents, women of reproductive age (including pregnancy) and older adults (representing ~70% of European society) as well as immigrant/ethnic minority groups and those affected by social inequality or poverty, are at risk of MN deficiencies. While addressing this public health problem is a priority, it is not possible until data on the prevalence of MN deficiencies across the EU population and the causes for these deficiencies is available to predict and identify those most at risk. Without this information, discussions on how to meet dietary requirements for the priority MNs of public health concern, and improve their status, take place in a vacuum. The Zero_HiddenHunger_EU project aims to 1) provide estimates of the true prevalence of MN deficiencies, based on priority biomarker and MN intake data in European populations and their associated health costs, focused on high-risk population subgroups, and 2) provide the best possible evidence to develop context-specific, tailored food-focused solutions to ensure adequate supply of vitamins and minerals from diets from sustainable sources. The consortium will focus the research effort around existing high-quality data resources and biobanks from diverse and representative population groups around Europe, supplemented by targeted studies in under-represented groups, maximizing research investment and adding value. Using high-throughput biomarker and advanced data analytical and modelling techniques, Zero_HiddenHunger_EU will deliver credible evidence enabling policymakers and food system actors to deliver food-focused strategies to eradicate MN deficiencies from Europe.

Тип пројекта:

HORIZON-RIA

From brain waves to memory boost: Memory enhancement by personalized frequency-modulated noninvasive brain stimulation

Project leader: Dr. Jovana Bjekić

Project collaborators: Dr. Katarina Vulić, Dr. Uroš Konstantinović, Dr. Saša Filipović, Dunja Paunović

Project number: 6058808

Duration of the project: 2020-2022.

Leading institution: Institute for Medical Research, University of Belgrade

Description of the project:

This project seeks to enhance the impact of transcranial direct current stimulation (tDCS) on memory by personalizing and optimizing the stimulation protocol for the parieto-hippocampal neural network. The project proposes an electrode positioning method that targets associative memory, a crucial function for remembering connected information. Unfortunately, associative memory deteriorates with age and is compromised in individuals with neurodegenerative conditions. The project also developed new frequency-modulated protocols and assessed their neurophysiological and behavioral effects. To further enhance the efficacy of the stimulation, the protocol was personalized to the individual theta rhythm. Theta rhythm is a neurophysiological marker of memory that appears in the electroencephalographic record when individuals attempt to remember or recall something. This project’s goal is to improve memory outcomes through customized and optimized tDCS protocols for the parieto-hippocampal neural network.

Тип пројекта:

National Projects

Etiology and prevention of thrombosis in hematologic malignancies

Project leader: Olivera Mitrović Ajtić

Project collaborators:

Vladan Čokić, Olivera Mitrović Ajtić, Dragoslava Đikić, Teodora Dragojević, Tijana Subotički, Milica Vukotić

Project number: 7749695

Duration of the project: 20.01.2022 . до 20.01.2025.

Leading Institution:

Institute for Medical Research, National Institute for Medical Research, University of Belgrade

Description of the project:

In order to discover the mechanism underlying frequent thrombosis in hematologic malignancies, it will be initiated the inflammation dependent activation and interplay of endothelial cells, platelets, and leukocytes with subsequent formation of microparticles and nitric oxide (NO) linked to thrombus generation by induction of coagulation and fibrinolysis. Cancer-associated thrombosis (CAT) is the second leading cause of death in cancer patients including both venous and arterial thromboembolism. While CAT can be treated with anticoagulants, benefits of therapy must be balanced with the increased bleeding risks. The coagulation related cells and biomarkers will be analyzed and selected by flow cytometry from the following hematologic malignancies: multiple myeloma, lymphoma, acute myeloid leukemia, and transplanted patients with graft-versus-host disease (GvHD). Besides clinical follow-up of the patients, extensive preclinical studies will be performed using in vitro cell cultures (hypoxia chamber, RT-qPCR, immunoassays), in vivo mouse models (NO analyzer), and in silico profiling. Activation of the coagulation factors will be observed through the prothrombotic properties of endothelium (microchip flow-chamber system), neutrophil extracellular traps (NETs, spectrophotometry) and anticancer treatments. The proposed study will show inflammatory stimulation of hypercoagulability, chemotaxis of immune response, and NET formation as well as modulation of fibrinolytic system and miRNA regulated platelet activation. In addition, the equilibrium between NO production and oxygen tension will largely influence the inflammation-dependent thrombus formation, with a prognostic significance of hypoxia related gene signature. Understanding the principal mechanisms may allow the development of new therapies to safely prevent CAT in the hematologic malignancies and GvHD, while determination of the specific biomarkers in each malignancy can be used as predictors of thrombosis.

Тип пројекта:

National Projects

Androgen dependent SARS-CoV-2 stimulation of hyperinflammatory response in COVID-19

Project leader: Vladan Čokić, MD, PhD

Project collaborators:

PI Vladan Čokić, P2 Juan F. Santibanez, P3 Olivera Mitrović Ajtić, P4 Milica Vukotić, P5 Dragoslava Đikić, P6 Tijana Subotički, P7 Teodora Dragojević

Project number: 7547934

Duration of the project: 001.3.2021. until 01.11.2022. years

Leading Institution: Institute for Medical Research, University of Belgrade

Description of the project:

Severe acute coronavirus virus syndrome 2 (SARS-CoV-2)-induced hyperinflammation is a major reason for severe clinical outcome of coronavirus disease 19 (COVID-19), principally in male patients. Cell entry of SARS-CoV-2 depends on binding to angiotensin-converting enzyme 2 (ACE2) and androgen-regulated transmembrane serine protease 2 (TMPRSS2). We propose a novel androgen-dependent mechanism of ACE2 activation by SARS-CoV-2 in endothelial and immune cells; as well as endothelial dysfunction and hyperinflammation stimulated immune response predispose to thrombus formation in COVID-19. SARS-CoV-2 will be isolated, in vitro expanded, and used to monitor cell signaling and cytokine storm by immune assays and viral load by RT-qPCR. Related androgen pathways will be pharmacologically targeted. Immune-endothelial cell co-cultures will be performed for thrombosis development. We expect androgen-dependent SARS-CoV-2 host cell infection and mediated inflammation in thrombotic complications. This translational research will reveal androgen pathways implication in SARS-CoV-2 infection and therapeutic strategies to speed up patient recovery.

Тип пројекта:

National Projects

Novel encapsulation and enzyme technologies for designing of new biocatalysts and biologically active compounds targeting enhancement of food quality, safety and competitiveness

Project leader: Dr. Branko Bugarski

Project collaborators: Dr. Vesna Ilić, Dr. Ivana Drvenica

Project number: III46010

Duration of the project: 2011-2019.

Leading institution: Faculty of Technology and Metallurgy, University of Belgrade

Description of the project:

Тип пројекта:

National Projects
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