Project leader: Dr Ivana Okić Đorđević

Project collaborators:

Dr Hristina Obradović, dr Drenka Trivanović, dr Ivana Drvenica, dr med Sanja Momčilović, number: 337-00-110/2023-05/36

Duration of the project: Jul 2023 – Jun 2025

Leading Institution:

Institute for medical Research, University of Belgrade

Collaborating Institution: Institute of cell biology, University of Ljubljana

Description of the project:

Human amniotic membrane (hAM) is an available, inexpensive, and biocompatible collagen-based extracellular matrix with the cells derived from human placenta. hAM and its derivatives possess anti-inflammatory and regenerative properties. Until now, hAM has been used for post-operative and post-traumatic skin defects, intra-oral and genital reconstruction, and ophthalmologic disorders.

In recent decades, the regenerative and modulatory properties of stem cells (SCs) have gained the attention of scientists indicating the possibility of their use in cell therapy. Periodontal ligament SCs (PDLSCs), obtained after tooth extraction for orthodontic reasons are recently discovered cells playing a crucial role in oral tissue homeostasis. Since the outcomes of currently available wound healing treatment approaches of oral tissues are expensive and sometimes not predictable, the search for new molecules with regenerative potential is an important goal in oral tissue regeneration. For this purpose, the objectives of this project include the influence of hAM on wound healing and regenerative potential of PDLSCs.