Contamination routes of human pathogenic micro-organisms (HPMO) to plants are poorly understood. Basic resources for agro-production, such as soils, water and fertilizers can play a role in contamination of plants, but micro-organisms taxonomical closely related with HPMO are also present plant microbiomes. The HUPLANTcontrol network consists of five working groups: 1) on the ecology of HPMO in plants, 2) on taxonomical identification of HPMO from plants, 3) on characterization of the potential human-threatening nature of HPMOs, 4) on sanitary and agricultural management procedures to control HPMO in plant production facilities and 5) on dissemination of achieved knowledge via connections between science groups and relevant stakeholders from agriculture, industry and public health authorities. The Action integrates molecular biology, bio-informatics, microbiology, ecology, agronomy, veterinary and clinical sciences and places a strong focus on primary plant production, in principle covering all micro-organisms posing potential threats to humans.