Project leader: Dr Nevena Mihailović Stanojević
Project collaborators:
Dr Nevena Mihailović Stanojević, dr Zoran Miloradović, dr Jelica Grujić Milanović, dr Đurđica Jovović, dr Milan Ivanov
Project number: 69-00-49/2010-02
Duration of the project: January 2011 – December 2012
Leading Institution:
University of Belgrade, Institute for Medical Research, Institute of national importance for the Republic of Serbia
Description of the project:
Extraction procedures for the preparation of plant extracts suitable for intravenous use under acute experimental conditions were developed to clarify the possible role of polyphenols and flavonoids from plants of the Lamiaceae family in the prevention and treatment of cardiovascular diseases. In addition, the qualitative and quantitative composition of bioactive compounds, especially polyphenols in the studied extracts, and the in vitro biological activity of the plant extracts in cell cultures were determined. Besides, the antihypertensive, antioxidant, and antiflipemic effects of extracts isolated from plants of the Lamiaceae family were studied in an experimental model of essential hypertension. Since the plant species studied are those that have long been used as beverages or herbal preparations, the aim of this project was to combine two complementary areas of research to define the composition and effects of plant extracts from the Lamiaceae family so that their consumption can ensure an adequate supply of biologically active compounds that may have beneficial effects on human health.