Cost Archives - Page 2 of 3 - Institute for Medical Research

In vitro total cell guidance and fitness

Project leader: Tiziana Brevini

Project collaborators:

Aleksandra Jauković (MC member), Drenka Trivanović (MC substitute), Tamara Kukolj, Hristina Obradović, Ivana Okić Đorđević

Project number: CA16119

Duration of the project: March 2017. – September 2021.

Leading Institution: Universita degli studi di Milano, Milano, Italija

Description of the project:

The aim of this COST Action is to refine the present understanding of in vivo micro/macro-environment in order to reproduce in vitro the physiological system in the best possible way: surface topography, substrate stiffness, mechanical stimulation, chemical cues and localized density will be analyzed. This will allow to develop reliable “3D total guidance” in vitro models reducing the number of animals used and allowing a safe translation of the present basic knowledge in cell repair and regeneration from the laboratory bench to the clinical application, with a positive impact on every day’s life patients and general Health costs. Researches in this field are being performed by different groups in the EU, but efforts need to be coordinated in order to avoid duplication, set targets and guidance for future research and to standardize protocols through a large interdisciplinary collaborative EU network. These goals can only be achieved under a COST program.

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Converting molecular profiles of myeloid cells into biomarkers for inflammation and cancer

Project leader : Sven Brandau

Project collaborators:

Juan F. Santibañez (MC Member), Slavko Mojsilović, Milica Vukotić

Project number: CA20117

Leading Institution: октобар 2021. – октобар 2025

Водећа институција: University Hospital Essen, Esen, Nemačka

Description of the project:

Myeloid immune cells are important mediators in the pathology of many diseases, especially in diseases associated with chronic inflammation (DACI). Recent advancements in molecular profiling technologies have led to the generation of large data sets, many of those not fully explored yet, but accessible to the entire scientific community via public data repositories. It is the aim of this COST Action to repurpose those data sets, retrieve and curate myeloid cell-specific information, and apply this information to develop novel biomarkers for DACI. To this end, Mye-InfoBank utilise COST networking tools to enable the interaction of molecular biologists, bioinformaticians, immunobiologists, biobank coordinators and clinicians. The concerted activity of these experts on myeloid cell biology (either basic or clinical research), bioinformatics, and bio-banking, will transform complex molecular information into standardised and applicable biomarkers, which have the potential to improve clinical decision making in a number of socio-economically important diseases.

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European Network of Investigators Triggering Exploratory Research on Myeloid Regulatory Cells

Project leader: Sven Brandau

Project collaborators:

Juan F. Santibañez (MC Member), Vladan Čokić (MC Substitute), Slavko Mojsilović, Jelena Krstić, Sunčica Bjelica

Project number: BM1404

Duration of the project: November 2014 – November 2018

Leading Institution: University Hospital Essen, Esen, Nemačka

Description of the project:

This Action formed a network of researchers and clinicians with the aim to establish a gold standard of common protocols and harmonize guidelines for the analysis and clinical monitoring of myeloid regulatory cells (MRCs). There is also a deficit in the translation of findings from animal models to humans, and Mye-EUNITER built an analytical mouse-monkey-man correlation line. Standardized and validated tools for MRC analysis aid the development of cellular biomarkers of disease and guide the design of novel therapies to manipulate the functions of MRCs. Members of the Action from IMR actively engaged in the activities of working groups through attending meetings, workshops, short-term scientific missions, and writing papers.

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International Network for Translating Research on Perinatal Derivatives into Therapeutic Approaches

Project leader : Ornella Parolini

Project collaborators: Diana Bugarski, Slavko Mojsilović, Hristina Obradović

Project number: CA17116

Duration of the project: October 2018 – April 2023

Leading Institution: Università Cattolica del Sacro Cuore, Rim, Italija

Description of the project:

This COST action aims to unite a currently fragmented critical mass of academic, clinical, and industry expertise to improve both the fundamental understanding and translational potential of perinatal derivatives. It includes participants with extensive know-how in basic research, clinical trials, regulatory affairs, and biomedical industry. SPRINT is joining forces to strengthen knowledge in the field and overcome the bottlenecks of translation to enable innovative therapeutic applications of perinatal-derived tissues, cells, and factors. Within Action Working Group 2, the IMR team worked to review preclinical studies in animal models to assess the efficacy of therapeutic interventions and identify research gaps, resulting in three papers co-authored by IMR team members.

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Towards аn International Network for Evidence-based Research in Clinical Health Research,

Project leader: Prof Hans Lund PT. PhD,

Project collaborators:

Member of the Management Committee of the action Vesna Vučić, Ph.D., deputy member Danijela Ristić-Medić, Ph.D. sci med

Project number: CA17117

Duration of the project: October 2018-April 2023

Leading Institution: Department of Mental Health Western Norway University of Applied Sciences, Univerzitet u Bergenu, Norveška

Description of the project:

Redundant clinical research has been published due to the absent use of systematic reviews (SR) when new research is planned. It is unethical, limits the available funding for important and relevant research, and diminishes the public’s trust in research. In order to raise awareness of this inappropriate practice, the EVBRES-consortium define “Evidence-Based Research” (EBR) as the use of prior research in a systematic and transparent way to inform a new study so that it answers the questions that matter in a valid, efficient and accessible manner. New studies should be informed by SRs as to the most appropriate design and methods. EVBRES will establish an international European-based network aiming to raise awareness of the need to use of SRs when planning new studies and when placing new results in context. PhD students and senior clinical researchers’ needs to learn how to find, critically appraise and update a SR, answering the same clinical question the new study plans to answer. Closely related to this is the involvement and awareness of related stakeholders, including patients, ethics committees, funding agencies and scientific journals, to require SRs before approval of new clinical studies. By acknowledging and implementing an EBR approach these stakeholders can improve their own practice and can increase the incentives for clinical researchers to use an EBR approach. Further, EVBRES will catalyse more efficient updating and production of SRs, and monitor the implementation of an EBR approach both in clinical research and among related stakeholders.

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Goat-parasite interactions: from knowledge to control

Project leader: Dr Smaragda Sotiraki

Project collaborators:

Olgica Djurković-Djaković (member of the management committee of the action), Ivana Klun, Tijana Štajner, Vitomir Djokić

Project number: FA0805

Duration of the project: April 2009 – January 2014.

Leading Institution: NAGREF Veterinary Research Institute, NAGREF Campus, Thermi 57001, Thessaloniki, Greece

Description of the project:

The main objective of the Action was to advance our knowledge on various aspects of goats’ parasitology and health management towards a better understanding of the different components explaining the specificities of goat-parasite interactions as well as to develop sustainable strategies to control parasitic diseases in goats.

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European Network of Bioadhesion Expertise: Fundamental Knowledge to Inspire Advanced Bonding Technologies

Project leader: Mr Janek VON BYERN

Project collaborators: Dr Darko Mihaljica

Project number: CA15216

Duration of the project: 2016-2021

Leading Institution:

Description of the project:

Many organisms, ranging from bacteria and fungi to those much larger animals and plants use chemical and mechanical means to attach permanently or temporarily to surfaces. Some bioadhesives have advantages over synthetic counterparts in terms of their ability to function over a wide temperature range, in wet or dry environments, and to form stable bonds within seconds to all manner of substrata, even those with challenging surface coatings. Knowledge about these materials, in terms of composition, structural design and interactions with surfaces, is necessary to reveal the basic biochemical and mechanical principles involved in biological adhesion. This COST Action will unite the widespread European expertise in the field of biological adhesives (spanning biology, physics, chemistry, and engineering) by streamlining and pooling knowledge, methods and techniques, and will focus activities by avoiding duplication of efforts, decreasing research costs, and accelerating scientific and technological progress in Europe.

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New approaches in detection of pathogens and aeroallergens

Project leader: Prof Carsten Ambelas SKJØTH

Project collaborators: Dr Gorana Veinović

Project number: CA18226

Duration of the project: 2019-2023

Leading Institution:

Description of the project:

Bioaerosols are among the most complex components in the atmosphere. Bioaerosols are relevant as important pathogens in crops and on trees, as aeroallergens in relation to human health and as catalysts for physical processes in relation to climate such as cloud formation processes. The last five to ten years a range of new techniques have become available that enable a number of scientific breakthroughs in the general understanding of bioaerosols and how they interact with the environment. This COST action will establish an interdisciplinary network of experts currently involved in the detection of bioaerosols using both existing methods as well as upcoming technologies such as real or near real-time technologies from atmospheric chemistry and physics or eDNA methods used in molecular biology. A main objective is to critically address the barriers that limits the penetration of new methods in detection of bioaerosols.

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Control of Human Pathogenic Micro-organisms in Plant Production Systems

Project leader: Dr Leo VAN OVERBEEK

Project collaborators: Dr Gorana Veinović

Project number: CA16110

Duration of the project: 2017-2021

Leading Institution:

Description of the project:

Contamination routes of human pathogenic micro-organisms (HPMO) to plants are poorly understood. Basic resources for agro-production, such as soils, water and fertilizers can play a role in contamination of plants, but micro-organisms taxonomical closely related with HPMO are also present plant microbiomes. The HUPLANTcontrol network consists of five working groups: 1) on the ecology of HPMO in plants, 2) on taxonomical identification of HPMO from plants, 3) on characterization of the potential human-threatening nature of HPMOs, 4) on sanitary and agricultural management procedures to control HPMO in plant production facilities and 5) on dissemination of achieved knowledge via connections between science groups and relevant stakeholders from agriculture, industry and public health authorities. The Action integrates molecular biology, bio-informatics, microbiology, ecology, agronomy, veterinary and clinical sciences and places a strong focus on primary plant production, in principle covering all micro-organisms posing potential threats to humans.

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