Bilateral Scientific Cooperation

Enhancement of the Stability and Bioavailability of Phytochemicals Using Different Delivery Systems and Mathematical Modeling of an In Vitro Gastrointestinal Simulation

Project leader: Dr. Ivana Drvenica, Dr. Tea Bilušić

Project collaborators:

Project number: 451-03-40/2016-09/17

Duration of the project: 2016-2017.

Leading institution:

Description of the project:

Тип пројекта:

Bilateral Scientific Cooperation

Hemoglobin from a Renewable Source as a Starting Material for a Heme Iron Product for the Prevention and Treatment of Anemia in Domestic Animals: Optimization of the Hemoglobin Isolation and Purification Process

Project leader: Dr. Vesna Ilić, Dr. Aleš Podgornik

Project collaborators: Dr. Ivana Drvenica

Project number: 651-03-1251/2012-09/27

Duration of the project: 2012-2013.

Leading institution:

Description of the project:

Тип пројекта:

Bilateral Scientific Cooperation

Effect of Dietary Lipids on Cardiovascular Parameters, Lipogenesis, and Antioxidant Status in Hypertensive Rats

Project leader: Dr. Jelica Grujić Milanović

Project collaborators: Dr. Nevena Mihailović-Stanojević, Dr. Danijela Karanović, Dr. Kristina Starčević, Dr. Tomislav Mašek, Dr. Maja Maurić

Project number: 337-00-205/2019-09/32

Duration of the project: 2019-2022.

Leading institution: Institute for Medical Research, University of Belgrade

Collaborating institution: Faculty of Veterinary Medicine, University of Zagreb, Croatia

Description of the project:

The main objective of this project was to determine the mechanism of action of high-fat foods of different origins (animal/plant) and the possibility of preventing the metabolic syndrome by modulating the n6/n3 ratio of dietary fats on the oxidative status and expression of various transcription factors that are part of the blood pressure regulatory system. The reason for this approach lies in the general public health interest in developing new strategies for the prevention and treatment of the metabolic syndrome and, consequently, of cardiovascular diseases, with the aim of reducing the number of people affected. Therefore, the aim of this project was to study the effects of a diet containing vegetable/animal fats with different ratios of n6/n3 lipids on the cardiovascular system and lipogenesis in different tissues under both physiological and pathological conditions.

Тип пројекта:

Bilateral Scientific Cooperation

Cardiac Remodelling Down the Calmodulin Kinase 2 Cascade

Project leader: Dr. Milan Ivanov

Project collaborators: Dr. Zoran Miloradović, Dr. Nevena Mihailović-Stanojević, Dr. Đurđica Jovović, Dr. Una-Jovana Vajić, Dr. Danijela Karanović, Dr. Senka Holcer, Dr. Simon Sedej, Dr. Nataša Đalinac

Project number: 451-03-02141/2017-09/44

Duration of the project: 2018-2020.

Leading institution: Institute for Medical Research, University of Belgrade

Collaborating institution: Medical University of Graz, Austria

Description of the project:

The main objective of this project was to characterize the spatial and temporal activation of signaling pathways for Ca2+/CaM/CaMKIIδC- and δB-kinases in defined subcellular areas of isolated adult ventricular cardiomyocytes and their influence on the initiation and progression of hypertrophy and heart failure. The project was performed on isolated rat cardiomyocytes and healthy and diseased human cardiomyocytes. This project enabled multidisciplinary collaboration of biologists, molecular biologists, biotechnologists and physicians from Austria and Serbia, which in the future will serve as a basis for the creation of a network of institutions for the development of modern approaches in experimental cardiovascular physiology. Complementarity of methods as well as scientific work and topics under in vivo and in vitro conditions of scientists from Austria and Serbia resulted in improvement of approach to solving problems in the field of cardiovascular physiology.

Тип пројекта:

Bilateral Scientific Cooperation

The Role of Nitric Oxide, Free Radicals, and Ang II Peptide in Vascular Structure and Function in Experimental Hypertension

Project leader: Dr. Zoran Miloradović

Project collaborators: Dr. Đurđica Jovović, Dr. Nevena Mihailović-Stanojević, Dr. Jelica Grujić Milanović, Dr. Kristek František, Dr. Soňa Čačányiová

Project number: СК-СРБ-0026-29

Duration of the project: 2010-2011.

Leading institution: Institute for Medical Research, University of Belgrade

Collaborating institution: Institute of Normal and Pathological Physiology SAS, Bratislava, Slovakia

Description of the project:

A chronic decrease in nitric oxide synthesis caused by blockade of the enzyme constitutive nitric oxide synthase results in a permanent increase in blood pressure associated with hypertrophy of the heart and arterial blood vessels. The aim of the study was to investigate the comparative effects of nitric oxide synthase inhibitors associated with vascular and cardiac changes. The long-term effects of the combined action of two types of nitric oxide synthase inhibitors on the heart and on the structure and function of blood vessels, as well as their effects on the cellular and extracellular components of the walls of conducting blood vessels in terms of the role of free radicals and the renin-angiotensin system, were investigated. The results obtained represent a contribution to the understanding of the basic regulatory mechanisms in hypertension and to the development of new approaches for the prevention and therapy of this disease.

Тип пројекта:

Bilateral Scientific Cooperation

Characterization of Extracts Isolated from Plants of the Lamiaceae Family and Evaluation of Their Antioxidant, Antilipemic, and Antihypertensive Effects In Vivo

Project leader: Dr. Nevena Mihailović-Stanojević

Project collaborators: Dr. Zoran Miloradović, Dr. Jelica Grujić Milanović, Dr. Đurđica Jovović, Dr. Milan Ivanov

Project number: 69-00-49/2010-02

Duration of the project: January 2011-December 2012.

Leading institution: Institute for Medical Research, University of Belgrade

Description of the project:

Extraction procedures for the preparation of plant extracts suitable for intravenous use under acute experimental conditions were developed to clarify the possible role of polyphenols and flavonoids from plants of the Lamiaceae family in the prevention and treatment of cardiovascular diseases. In addition, the qualitative and quantitative composition of bioactive compounds, especially polyphenols in the studied extracts, and the in vitro biological activity of the plant extracts in cell cultures were determined. Besides, the antihypertensive, antioxidant, and antiflipemic effects of extracts isolated from plants of the Lamiaceae family were studied in an experimental model of essential hypertension. Since the plant species studied are those that have long been used as beverages or herbal preparations, the aim of this project was to combine two complementary areas of research to define the composition and effects of plant extracts from the Lamiaceae family so that their consumption can ensure an adequate supply of biologically active compounds that may have beneficial effects on human health.

Тип пројекта:

Bilateral Scientific Cooperation
1 2
This site is registered on wpml.org as a development site.