Main scientific programs are related to the investigations of:

 

  • expression of ghrelin and its receptors in human stomach and pancreas during prenatal and early postnatal development -relationship to other hormones
  • HER-2 and TOP2A gene status and their correlation with Bcl-2, p53, Ki67, ssDNA, and clinicopathological parameters in four molecular subtypes of breast cancer
  • role of nitric oxide in the effects of ethanol as a stressor on HPA axis and mucosal immune system
  • cellular and molecular mechanisms underlying erythropoietic response to chronic psychological stress
  • pathogenesis of hematological malignancies with special reference to angiogenesis and oxidative stress
Mirela Budec
Mirela Budeč, MD., PhD.

Professor of Research

PROJECTS & EDUCATION

  • Lokalna neuroendokrino-imunološka osovina kod inflamacije gastrointestinalnog trakta (GIT) – molekularnopatološka, biohemijska i imunohistohemijska istraživanja (2006-2010)
  • The pathogenetic mechanism in hematological malignancies (OI175053, 2011-2015)
  • Regulatorni peptidi, citokini i faktori rasta neuroendokrinoimunološke osovine u ontogenezi, onkogenezi i inflamaciji digestivnog trakta (2001-2005)
  • A bilateral SCOPES project with Switzerland (2014-2016): “Determination of the mutational landscape and clonal architecture and its application in angiogenesis and thrombosis of MPN patients” funded by Swiss National Science Foundation as Joint research project.
  • COST action: European Network of Investigators Triggering Exploratory Research on Myeloid Regulatory Cells (Mye-EUNITER, BMBS COST Action BM1404, 2014-2018)
  • Čokić Vladan: Gene expression profile of hematopoietic progenitor cells vs. granulocytes in myeloproliferative neoplasms. Symposium “Molecular and genetic characteristics of hematopoiesis in hematological malignancies”, School of Medicine, University of Belgrade, 02.09.2011. Sastanak je akreditovan kod Zdravstvenog saveta RS kao međunarodni kurs (5 KME bodova).
  • Two Ph. thesis. are carried out within group.
Domestic:

International:

TEAM MEMBERS

Mirela Budec
Mirela Budeč, MD., PhD.

Professor of Research

Olivera-Mitrovic-Ajtic
Olivera Mitrović Ajtić, PhD.

Assistant Professor of Research

Dragoslava
Dragoslava Ðikić, MD, Msc

Research Associate

Sanja Vignjevic
Sanja Vignjević Petrinović, MD, PhD

Assistant Professor of Research

Tijana Suboticki
Tijana Subotički, BSc, PhD

Research Associate

Marijana Buac
Marijana Buač, MSc

Research Associate, PhD Stud

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SELECTED PAPERS

  • Vignjević Petrinović S, Budeč M, Marković D, Gotić M, Mitrović Ajtić O, Mojsilović S, Stošić-Grujičić S, Ivanov M, Jovčić G, Čokić V. Macrophage migration inhibitory factor is an endogenous regulator of stress-induced extramedullary erythropoiesis. Histochem Cell Biol 2016 Sep;146(3):311-24., DOI 10.1007/s00418-016-1442-7.
  • Čokić VP, Mossuz P, Han J, Socoro N, Beleslin-Čokić BB, Mitrović O, Subotički T, Diklić M, Leković D, Gotić M, Puri RK, Noguchi CT, Schechter AN. Microarray and Proteomic Analyses of Myeloproliferative Neoplasms with a Highlight on the Mtor Signaling Pathway. PLoS One 2015 Aug 14; 10 (8):e0135463. doi: 10.1371/journal.pone.0135463. eCollection 2015.
  • Čokić VP, Mojsilović S, Jauković A, Kraguljac-Kurtović N, Mojsilović S, Šefer D, Mitrović Ajtić O, Milošević V, Bogdanović A, Đikić D, Milenković P, Puri RK. Gene expression profile of circulating CD34(+) cells and granulocytes in chronic myeloid leukemia. Blood Cells Mol Dis 2015 Dec;55(4):373-81. doi: 10.1016/j.bcmd.2015.08.002. Epub 2015 Aug 7.
  • Čokić VP, Mitrović-Ajtić O, Beleslin-Čokić BB, Marković D, Buač M, Diklić M, Kraguljac-Kurtović N, Damjanović S, Milenković P, Gotić M, Raj PK. Proinflammatory Cytokine IL-6 and JAK-STAT Signaling Pathway in Myeloproliferative Neoplasms. Mediators Inflamm 2015; 453020. doi: 10.1155/2015/453020. Epub 2015 Sep 29. (IF = 3,236; Имунологија, 58/148, 2014)
  • Mitrović-Ajtić O, Todorović S, Diklić M, Subotički T, Beleslin-Čokić BB, Jovčić G, Čokić V. Proliferation and differentiation markers of colorectal adenocarcinoma and their correlation with the clinicopathological factors. Turkish Journal of Medical Sciences, IN PRESS, 2015.
  • Vignjević S, Budeč M, Marković D, Dikić D, Mitrović O, Diklić M, Subotički T, Čokić V, Jovčić G. Glucocorticoid receptor mediates the expansion of splenic late erythroid progenitors during chronic psychological stress. J Physiol Pharmacol. 2015, 66(1):91-100.
  • Cokic VP, Bhattacharya B, Beleslin-Cokic BB, Noguchi CT, Puri RK, Schechter AN. JAK-STAT and AKT pathway-coupled genes in erythroid progenitor cells through ontogeny. J Transl Med. 2012;10:116.
  • Čokić VP, Smith RD, Biancotto A, Noguchi CT, Puri RK, Schechter AN. Globin gene expression in correlation with G protein-related genes during erythroid differentiation. BMC Genomics. 2013 ;14:116.
  • Vignjević S, Budeč M, Marković D, Djikić D, Mitrović O, Mojsilović S, Vranješ Đurić S, Koko V, Beleslin Čokić B, Čokić V, Jovčić G. Chronic psychological stress activates BMP4-dependent extramedullary erythropoiesis. J Cell Mol Med; 2014;18(1):91-103.
  • Mitrović O, Čokić V, Đikić D, Budeč M, Vignjević S, Subotički T, Diklić M, Ajtić R. Ghrelin receptors in human gastrointestinal tract during prenatal and early postnatal development. Peptides. 2014 Jul;57:1-11.
  • Budeč M, Marković D, Vignjević S, Mitrović O, Dikić D, Koko V, Čokic VP. Neuronal nitric oxide synthase mediates the effect of ethanol on IgA. Alcohol Alcohol 2013, 48(1):53-8.
  • Mitrović O, Cokić V, Dikić D, Budeč M, Vignjević S, Subotički T, Gulan M, Radović S, Furtula S. Correlation between ER, PR, HER-2, Bcl-2, p53, proliferative and apoptotic indexes with HER-2 gene amplification and TOP2A gene amplification and deletion in four molecular subtypes of breast cancer. Target Oncol. 2013 Nov 24.
  • Vignjević S, Todorović V, Damjanović S, Budeč M, Mitrović O, Djikić D, Drndarević N, Micić M, Krivokapić-Misković J, Djuričić S, Nikolić I. Similar developmental patterns of ghrelin- and glucagon-expressing cells in the human pancreas. Cells Tissues Organs 2012;196(4):362-73.
  • Mitrović O, Mićić M, Radenković G, Vignjević S, Ðikić D, Budeč M, Breković T, Čokić V. Endocrine cells in human fetal corpus of stomach: appearance, distribution, and density. J Gastroenterol 2012, 47(11):1212-20.
  • Đikić D, Budeč M, Vranješ-Đurić S, Todorović V, Drndarević N, Vignjević S, Mitrović O. Ethanol and nitric oxide modulate expression of glucocorticoid receptor in the rat adrenal cortex. Pharmacological Rep 2012; 64:(4) 896-901.
  • Đikić D, Budeč M, Vranješ-Đurić S, Koko V, Vignjević S, Mitrović O. The acute effect of ethanol on adrenal cortex in female rats-possible role of nitric oxide. Alcohol Alcohol 2011, 46(5):523-8.
  • Mitrović O, Mićić M, Todorović V, Radenković G, Vignjević S, Đikić D, Budeč M, Breković T. Ghrelin endocrine cells in the human stomach during prenatal and early postnatal development Arch Biol Sci Belgrade, 2011, 63 (1), 21-28.
  • Budeč M, Marković D, Djikić D, Mitrović O, Drndarević N, Koko V, Todorović V. Blockade of nitric oxide synthesis modulates rat immunoglobulin A. Neuroimmunomodulation 2009; 16(3):155-61.
  • Budeč M, Koko V, Todorović V, Marković D, Postić D, Drndarević N, Spasić, A, Mitrović O. Possible mechanism of acute effect of ethanol on intestinal IgA expression in rat. Int Immunopharmacol 2007, 7(6):858-863.