The Laboratory for Medical Entomology was formed along with the establishment of Institute for Medical Research, under the title “Laboratory for Medical Arachnoentomology”. The research activities performed in the Laboratory since its establishment include various aspects of biology, faunistic studies, ecology and epidemiology of medically important insects (mosquitoes, simulids, phlebotomines), with a focus on vector species and vector-transmitted pathogens. Some of the most important research results in this period include the first isolation of Tahyna virus from female mosquitoes of species Aedes vexans, isolation of virus of phlebotomic fever – Napoli type, and isolation of virus Jug Bogdanovac, which was included in the international catalogue of arboviruses as the first virus recorded in a Balkan country. During the 1980s the first systematic faunistic-ecological studies on ticks started in the frame the Laboratory activities. These exhaustive studies included two approaches: faunistic and ecological, with a special accent on population ecology and dynamics of tick species, their importance from the biomedical aspect, host-parasite relationships, with the common goal of better understanding of epidemiological factors in various regions of Serbia.
As within the region of Serbia ticks are the most important arthropod vectors, the contemporary research in the Laboratory is primarily targeting this group of organisms and their importance as ectoparasites, reservoirs and vectors of tick-transmitted pathogens (Babesia spp., Borrelia spp., Rickettsia spp., Anaplasma spp., Ehrlichia spp., Coxiella burnetii, Francisella spp., Bartonella spp., virus of Crimean-Congo hemorrhagic fever, virus of tick-borne encephalitis). The research activity has several parallel focus points: population-genetic studies of vectors; studies of enzootic transmission cycles of pathogenic microorganisms transmitted by ticks; isolation, cultivation and genotypification of tick-borne pathogens important for human and veterinary medicine (especially Borrelia burgdorferi s.l.); studies on function of components of tick saliva and their potential use. The study techniques include use of various entomological methods (collecting samples in the field, laboratory work), establishment and maintenance of laboratory lines of ticks, methods of pathogen detection through use of microscopy (classical and dark field microscopy), molecular methods, microbiological methods, immunological methods etc. One of the key results of these studies is updating the ecological profiles of vectors, including the summarized information on geographic distribution, potential hosts, and role in transmission of pathogenic organisms, bionomics and habitats inhabited by each species. The collected data are used for geographic information system (GIS) and development of mathematical predictive models. The study results also have applicative significance in clinical practice. Knowledge of diversity and characteristics of pathogens at the local level is crucial for reliable diagnostics and efficient prevention, as the variations in genetic structure of pathogens cause differences in pathogenic potential, virulence and clinical manifestations of diseases.
Transfer of knowledge derived through research activities is performed through expertise in diagnostics of vector-transmitted pathogens in human and animal populations, as well as through risk assessments and design and development of new strategies for control of distribution and transmission of vector-borne pathogens.
Snezana Tomanovic
Snezana Tomanovic, PhD

Associate Research professor

PROJECTS & EDUCATION

  • 1986-1990 “Research on fauna of Ixodidae in territory of SR Serbia”, SASA board for fauna
  • 1991-2000 “Infective agents in medicine”
    • subproject (1991-1995) “Immunological and epidemiological research on certain protozoans, helminthes and hematophagous arthropods and associated diseases”, Ministry for Science and Technology of Serbia.
    • subproject (1996-2000) “Research on hematophagous arthropods and their role in transmitting parasitic and viral diseases”
  • 1994-1997 “Ecological research on hematophagous arthropods and their role in transmitting parasitic and viral diseases of humans”, Federal Ministry of Science, Technology and Development.
  • 1994-1998 “Determining the presence of ticks (Acari: Ixodidae) and their infestation with protozoans”, Ministry of Science, Technology and Development.
  • 2002-2005 “Ticks as reservoirs and vectors of pathogenic organisms”; Federal Ministry of Science, Technology and Development.
  • 2006-2010 “Infections with intracellular microorganisms of increasing importance: transmission, relationship pathogen-host, molecular epidemiology and clinical significance” (145002), Ministry of Science and Technological Development.
  • 2011-2015 “Enzootic transmission cycles of pathogenic microorganisms transmitted by ticks” (OI173006), Program of Basic Research by Ministry of Education, Science and Technological Development – Head of project: PhD Snežana Tomanović.
  • Reinforcement of the Serbian Centre for Parasitic ZoonosesSERBPARZOON (FP6-2005-INCO-WBC/SSA-3), (2007-2009)
  • 2013-2017 European Network for Neglected Vectors and Vector-Borne Infections ( Action TD1303 – EURNEGVEC) Dr Snežana Tomanović je član Working Group-a 3 i 4

Bilatheral projects

  • 2010-2011 Distribution of genospecies of Borrelia burgdorferi sensu lato, causative agents of Lyme disease in Slovenia and Serbia, bilatheral project Slovenia-Serbia (principal investigator dr Snežana Tomanović)
  • 2013-2015 Epidemiological risk models for vector borne diseases in a changing world. The case study of mosquito and tick-borne diseases under different conditions of habitat integrity, environment and climate”, Bilatheral project Serbia-Italy (Dr Snežana Tomanović, Sanja Ćakić i Darko Mihaljica members of the project team)
  • dr Snežana Tomanović – accreditated mentor for PhD courses, Faculty of Biology, University of Belgrade
  • dr Snežana Tomanović – accreditated lecturer for PhD courses, Faculty of Biology, University of Belgrade
  • dr Snežana Tomanović – invited lecturer, Faculty of Biology, University of Belgrade
  • “Determination of species, stadium and engorgement of tick samples” – 300,00 RSD

  • “Detection of Borrelia burgdorferi sensu lato in tick samples by dark field microscopy“ – 700,00 RSD

  • “Molecular detection of Borrelia burgdorferi sensu lato in tick samples by PCR methods ( flaB, rrf-rrl and 16S rRNA gene)” – 2500,00 RSD

TEAM MEMBERS

Snezana Tomanovic
Snezana Tomanovic, PhD

Associate Research professor

Sanja Cakic
Sanja Cakic, MSc

Research Assistant

Darko Mihaljica
Darko Mihaljica, MSc

Research Assistant

Ratko Sukara
Ratko Sukara, DVM

Research Trainee

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SELECTED PAPERS

  • Stratimirovic Dj, Milosevic S, Blesic S, Ljubisavljevic M. Wavelet analysis of discharge dynamics of fusimotor neurons. Physica A, 291, 13-23, 2001.
  • Jaric S. Changes in movement symmetry associated with strengthening and fatigue of the agonist and antagonist muscles Journal of Motor Behavior, 32:9-16., 2000
  • Laczko J, Jaric S, Tihanyi J, Zatsiorsky VM, Latash ML. Components of the end- effector jerk during voluntary arm movements. Journal of Applied Biomechanics, 16:14-25, 2000
  • Milanovic S, Blesic S, Jaric S. Changes in movement variables associated with the transient overshoot of the final position. Journal of Motor Behavior, 32:115-120, 2000
  • Kostyukov AI, Day S, Hellstr�m F, Radovanovic S, Ljubisavljevic M, Windhorst U, Johansson H. Fatigue-related changes in EMG-activity of the cat gastrocnemius during frequency- modulated efferent stimulation. Neuroscience, 97(4):801-809, 2000
  • Kostyukov AI, Hellstr�m F, Korchak OE, Radovanovic S, Ljubisavljevic M, Windhorst U, Johansson H. Fatigue effects in the cat gastrocnemius during frequency- modulated efferent stimulation. Neuroscience, 97(4):789-799, 2000
  • Popovic D. , A. Stojanovic , Vulovic, Pjanovic, Radosavljevic, M. Popovic Clinical evaluation of the Bionic glove, Arch Phys Med and Rehab, 80, 299-304 (1999)
  • Maksimovic R. and M. Popovic, Classification of tetraplegics through automatic movement evaluation, Medical Engineering& Physics, 21, 310-324 (1999).
  • Ellaway PH, Day NJ, Ljubisavljevic M. Magnetic stimulation of the nervous System. In: U. Windhorst and H. Johannson (Ed.) Modern Techniques in Neuroscience Research, Chapter 33, pp. 869-889, Spriger Ferlag, Chapter, 1999.
  • Ljubisavljevic M. and M. Popovic, Data acquisition, processing and storage. In: U. Windhorst and H. Johannson (Ed.) Modern Techniques in Neuroscience Research, Chapter 45, pp. 1277-1309, Springer-Verlag, 1999.
  • Popovic, D. and M. Popovic, Nonanalitical Control for assisting reaching in humans with disability, in Winters J. and Crego P.E. (Ed.) Biomechanics and Neural Control of movement, Chapter 39: Rehabilitation Technologies and Performance, Springer-Verlag, 1999, in press.
  • S. Jaric, S. Milanovic, S. Blesic, M.L. Latash. Changes in movement kinematics during single-joint movements against expectedly and unexpectedly changed inertial loads, Human Movement Science 18 (1)) pp. 49-66 (1999)
  • Jaric S, Blesic S, Milanovic S, Radovanovic S, Ljubisavljevic M, Anastasijevic R. Changes in movement final position associated with agonist and antagonist muscle fatigue. Eur J Appl Physiol, 80: 467-471 (1999).
  • Blesic S, Miloševic S, Stratimirovic Dj, Ljubisavljevic M. Deetrended fluctuation analysis of time series of a firing fusimotor neuron. Physica A, 268: 275-282 (1999).