The Centre of Research Excellence in Nutrition and Metabolism (CENM) is part of IMR involved into fundamental and applied nutritional research in Serbia and region of West Balkan countries. The Centre is consist of food scientists,   nutritional researchers, medical doctors, molecular biologists, pharmacists, biochemists and bioinformatics all of whom are active in basic and applied nutritional research, most advanced country’s studies on nutrition, food and human health.

  • Our researchers are active in basic and applied nutritional research, most advanced country’s studies on nutrition, food and human health.
  • The research focuses on determining the nutrient requirements necessary to promote well-being for children and adults.
  • Our scientists examine how nutrition plays a role in the prevention of the major diseases affecting modern man today and conditions associated with aging.

Basic Research

The Centre of Research Excellence in Nutrition and Metabolism is dedicated to understanding why there are individual as well as epidemiological differences in nutrient requirements and metabolism. Using recent advances in nutritional science and molecular biology, the CENM is using the synergistic approaches between basic bio-medical sciences and clinical research and between clinical research and population health research with common goal of better understanding the nutrient role and action underlying obesity and diabetes.

Marija Glibetic
Marija Glibetić, PhD

Head of Department Senior Researcher

ORGANIZATIONAL STRUCTURE

Objectives:

  • To determine lipid status – total cholesterol, HDL- and LDL-cholesterol and triglyceride level and to assess the risk of cardiovascular disease (CVD).
  • To determine the fatty acids profile in plasma and/or erythrocyte phospholipids and to investigate relations between fatty acid profiles and various disease including CVD, cancer, obesity, metabolic syndrome and chronic inflammation.

Scientific results:

Our results showed significantly altered fatty acid profile in patients with CVD, cancer, diabetes and metabolic syndrome. Furthermore, abnormal profiles were also found in pregnant women with preeclampsia and in babies small for gestational age. In addition, different status of fatty acid was detected in elite athletes, but the changes are related to type of sport. These results have been published in a number of international journals.

Objective:

To examine the effects of treatment with different food supplements and active substances in order to get information’s about biochemical plasma parameters, phospholipids fatty acids profiles in tissues and plasma and oxidative stress parameters.

Established experimental models:

Model of aging (Wistar rats 22 months)

  • Effects of fish oil treatment in aging were examined in changes of biochemical parameters, parameters of oxidative stress as well as fatty acids profiles of phospholipids in tissues (liver), plasma and erythrocytes; there were differences comparing results between young and aged Wistar rats and also between correlated parameters.
  • Effects of n-3 fatty acids is followed with low and high doses of folates on the mentioned parameters. For now experiment were done on 3 months old Wistar rats.
  • Experiment which are followed would be with aged rats in same experimental conditions and examined parameters.
Objectives:

LMCBI is a new and young laboratory aiming at developing and scientifically exploiting cellular and tissue in vitro models. The following experimental models are established:

  • STEM CELL LINES – Isolation, cultivation and exploitation in relation to pathophysiological manifestation, such as liver cirrhosis or metabolic disorder
  • TISSUE ORGANOCULTURES – Isolation, cultivation and exploitation
  • COMMERCIAL CELL LINES – Cultivation, maintaining and exploitation
  • BIOBANKED HUMAN SAMPLES – Ex vivo experiments

Methods:

  • Standardized procedures for preparation of primary cell cultures
  • Standardized procedures for isolation of stem cells
  • Standardized procedures for cultivation and maintaining of primary and permanent cell cultures in appropriate cell media, such as RPMI, DMEM etc, with the addition of particular supplementation
  • Flow cytometer analyses for elucidation of cellular and molecular checkpoints during cell cycle, cell death, disturbed oxidative conditions etc, as well as immunoreactivity phenomena
  • Western blot analyses for determination of protein amounts, intracellular and inside ECM (extracellular matrix)
  • Construction of in vitro cellular models including transwell and transmembrane models for elucidation of cellular motility and migratory potential, as well as metastatic capacity, and gut permeability
Objective:

Laboratory for mathematical modeling and statistical analysis aims to support evidence-based nutritional research by applying statistical methodology, and to become regional center for nutritional epidemiology.

Methods:

  • Involved in development of nutritional software tools as to propose functions to enable efficient statistical analyses of the collected data.
  • Performing statistical analyses of the raw data using the most advances software packages such as SAS, STATA, SPSS and R.
  • Assisting in systematic literature reviewing and performing meta-analyses, when applicable.
  • Developing innovative modeling within European Commission funded project CHANCE, FP7, as to help to identify low cost nutritionally affordable foods for population at risk of poverty.
Objectives:

Public health nutrition focuses on the promotion of good health through nutrition and the primary prevention of diet-related illness in the population. The emphasis is on the maintenance of wellness in the whole population (definition: Nutrition Society UK).

 

The Department’s aims are to improve health in Serbia through excellence in public health nutrition (PHN) research, and to become regional center for PHN research and training in the Balkans. It is done by working on research projects in partnership with leading European academic institutions and by establishing and conducting PHN capacity development activities in Central and Eastern Europe (CEE).

Scientific results:

Capacity development in food and nutrition:

  • The first Serbian online food composition data base harmonized with EuroFIR recommendations
  • Balkan Food Platform with the 1st Regional online food composition data base harmonized with EuroFIR recommendations
  • Capacity Development Network in Nutrition in Central and Eastern Europe, NCDNCEE-CAPNUTRA (capnutra.org)
Objective:

The main activities of the Laboratory for Dietary Intervention Studies of CENM include the design and conduction of dietary intervention studies aiming to elucidate the effects of nutrients and non-nutritive dietary compounds in the prevention of chronic diseases, with the special focus on the prevention of cardiovascular diseases (CVD).

Methods:

The core of the research activities are randomised, double blind, placebo controlled dietary intervention studies, with parallel and cross-over assignment as intervention models.

Based on the purpose the studies involve:

  1. Healthy volunteers – in studies targeted to the primary prevention
  2. Subjects at high risk for CVD including obese, hyperlidemic, hyperglycemic subjects, subjects with metabolic syndrome, high blood pressure or healthy subjects with unhealthy life style (ie. smoking, unhealthy dieatry regiments) – in studies targeted to the secondary prevention
  3. Subjects with CVD or diabetes – in studies targeted to the tertiary CVD prevention (prevention of complications of the diseases).
Objective:

Dissemination and Implementation Research in Health: Translating Science to Practice

Dissemination and implementation (D&I) research seeks to understand how to best apply scientific advances in the real world, by focusing on pushing the evidence-based knowledge base out into routine use.  Besides scientific research, CENM has a specific role to “translate” nutrition science in a way that can be used by industry, policy makers and practitioners to deliver real improvements to human health. Therefore knowledge exchange and transfer is an explicit part of the CENM mission.

Methods:

CENM web portal (www.srbnutrition.info), CAPNUTRA (www.capnutra.org) and Agroweb Serbia (www.agrowebcee.net/awsr) provide an easy access to the diverse food and nutrition information in order to improve capacity building in nutrition. The   scope  of   information dissemination via mentioned web portals provide as well information about:

 

  • training possibilities,
  • educational programs and
  • links to calendars for upcoming food and nutrition-related events and conferences.

List of links helps nutrition professionals to locate information and materials for specific nutrition topics,  opening of wider communication and to moving from one-way information streams to geometric engagements.

In order to prevent disease, improve the health and education about proper and balanced nutrition, counseling office for diet and nutrition is a part of CENM.

  • Adequate nutrition is a key factor in maintaining and improving health!!

Many medical conditions either develop or are made worse by an improper or unhealthy diet.

The fields of consultations:

  • Treatment of eating disorders -diet regimens to assess nutritional status and biochemical parameters (using Body Shape Questionnaire – BSQ)
  • Diet therapy related to different patho-physiological states.
  • Hepato-gastroenterology counseling for nutrition in cooperation with the clinics.
  • Tips for feeding according to the fatty acid profile of serum and red blood cell-like biomarkers of fatty acid intake and changes in cell structure.
  • Counseling for nutrition in the prevention and treatment of malignancy (diet during radiation treatments, application of chemotherapeutic agents, interaction with food and immunosuppressive drugs).
  • Counseling for nutrition in renal (nephrotic syndrome, peritoneal dialysis, hemodialysis).
  • Obese patients receive and structured program of physical activity and adequate exercise in order to effectively weight reduction.

PROJECTS & EDUCATION

  • BACCHUS FP7 – Beneficial effects of dietary bioactive peptides and polyphenols on cardiovascular health in humans (2011 – 2015), (http://www.bacchus-fp7.eu/)
  • ODIN FP7 – Food-based solutions for Optimal vitamin D Nutrition and health through the life cycle (2013-2017)
  • CHANCE FP7 Low Cost tecHnologies and traditional ingredients for the production of Affordable, Nutritionally correct, Convenient foods enhancing hEalth in population groups at risk of poverty (2011-2014), (www.chancefood.eu)
  • EuroFIR Nexus FP7– EuroFIR Food Platform: Further integration, refinement and exploitation for its long-term self-sustainability ( 2011-13) (www.eurofir.org)
  • BaSeFOOD FP7 – Sustainable exploitation of bioactive components from the Black Sea Area traditional foods (BaSeFOOD), (2009-2012), (www.basefood-fp7.eu)
  • EURRECCA FP6– Harmonising nutrient recommendations across Europe with special focus on vulnerable groups and consumer understanding (NoE) (2007-2012) (www.eurreca.org)
  • EuroFIR FP6 -European Food Information Resource Network (NoE) (2006-2011), (www.eurofir.org)
  • DIETS, Dieticians Improving Education Training Standards across Europe, Thematic Network for Dieticians in Europe, Socrates Erasmus fund 2007-2100, (www.thematicnetworkdietetics.eu)
  • European Food Safety Authority (EFSA) project: Updated food composition database for nutrient intake (2012)
  • European Food Safety Authority (EFSA) “Dietary monitoring tools for risk assessment” (2012-2013)
  • POSITIVe, COST Action FA1403:  Interindividual variation in response to consumption of plant food bioactives and determinants involved (2014 -2018) (http://www.cost.eu/COST_Actions/fa/Actions/FA1403)
  • Bilateral project with Croatia: Folate status in populations at risk: young adult women of reproductive age and elderly (2011-2013)
  • Biological effects, nutritional intake and status of folate and polyunsaturated fatty acids: The improvement of nutrition in Serbia”, 2011-2015, III 41030, Ministry of Science, Republic of Serbia: FOLOMEGA
  • Bilateral project with France “Pavle Savić”: Identification of cellular and molecular targets of plant bioactives on human blood cells: clinical and in-vitro studies, (IMR-INRA), (2012-2013)
  • Media training for food and nutrition scientists; Media Actions for the International Training of Researchers (MAITRE) – December 2013, Belgrade, Serbia, work in progress
  • First Symposium of the Capacity Development in Nutrition and Food Research in Central and Eastern Europe (CAPNUTRA): Balkan Food Platform – Regional Food Composition Data Base development, 21-23 January 2013, Belgrade, Serbia
  • 6th Meeting/Workshop of the UNU/SCN Network for Capacity Development in Nutrition in Central and Eastern Europe (NCDNCEE), 25- 26 May 2011, Belgrade, Serbia
  • Regional Workshop for Food Composition; Data Base Development, 11.06.2010, Belgrade, Serbia
  • The 5th Meeting of the UNU/SCN Network for Capacity Development in Nutrition in Central and Eastern Europe (NCDNCEE), 11-12. 11.2009, Belgrade, Serbia
  • BaseFood Food Indexing Training Workshop, 9-11 November 2009, Belgrade, Serbia
  • 4th Meeting of the UNU/SCN Network for Capacity Development in Nutrition in Central and Eastern Europe (NCDNCEE), 10-12 November 2008, Belgrade, Serbia; Report on Capacity Development EURRECA-Training workshop for non-EURRECA members NCDNCEE for grey literature,
  • 3rd Meeting of the UNU/SCN Network for Capacity Development in Nutrition in Central and Eastern Europe(NCDNCEE), 1st – 2nd November 2007, Belgrade, Serbia
  • EuroFIR workshop “Training and Capacity Building for non EuroFIR CEE Countries“, 5th June 2007, Belgrade, Serbia

TEAM MEMBERS

Marija Glibetic
Marija Glibetić, PhD

Head of Department Senior Researcher

Mirjana Gurinovic
Mirjana Gurinović, PhD

Senior Researcher

Vesna Vucic
Vesna Vučić, PhD

Research associate professor

Danijela Ristic-Medic
Danijela Ristić-Medić, PhD

Scientific Associate

Gordana Petrovic – Oggiano
Gordana Petrović – Oggiano, MD, PhD

Scientific Associate

Tamara Popovic
Tamara Popović, PhD

Scientific Associate

Aleksandra Arsic
Aleksandra Arsić, Phd

Scientific Associate

Aleksandra Konic Ristic
Aleksandra Konić Ristić

Scientific Associate

marija postic
Marija Poštić, MSc

Research Associate

Ivana Karadzic
Ivana Karadžić, PhD Stud

Scientific Associate

Marina Nikolic
Marina Nikolić

Statistician

Marija Ranic
Marija Ranić, Phd Stud

Research Associate

Jasmina Debeljak Martacic
Jasmina Debeljak Martačić, Phd Stud

Scientific Associate

Marija Djekic Ivankovic
Marija Djekic Ivankovic, Phd Stud

Research Associate

Jasna Tepsic
Jasna Tepšić, Phd Stud

Research Associate

Snjezana Petrovic
Snježana Petrović, PhD

Scientific Associate

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SELECTED PAPERS

2014

  • Ristić-Medić D, Dullemeijer C, Tepsić J, Petrović-Oggiano G, Popović T, Arsić A, Glibetić M, Souverein OW, Collings R, Cavelaars A, de Groot L, Van’t Veer P, Gurinović M. Systematic review using meta-analyses to estimate dose-response relationships between iodine intake and biomarkers of iodine status in different population groups. Nutrition Reviews. 2014;72(3):143–61.
  • Gurinović M, Novaković R, Satalić Z, Nikolić M, Milešević J, Ranić M, Glibetić M. Professional training in nutrition in Central and Eastern Europe: current status and opportunities for capacity development. Public Health Nutrition. 2014 Feb27:1-6; doi:10.1017/S1368980014000172;
  • Karadzic I, Vucic V, Jokanovic V, Debeljak-Martacic J, Markovic D, Petrovic S, Glibetic M. Effects of novel hydroxyapatite based 3D biomaterials on proliferation and osteoblastic differentiation of mesenchymal stem cells. Journal of Biomedical Materials Research. Part A. 2014 Mar 25;doi: 10.1002/jbm.a.35180.
  • Iglesia I, Mouratidou T, González-Gross M, Novakovic R, Breidenassel C, Jiménez-Pavón D, Huybrechts I, De Henauw S, Geelen A, Gottrand F, Kafatos A, Mistura L, de Heredia FP, Widhalm K, Manios Y, Molnar D, Stehle P, Gurinovic M, Cavelaars AE, Van’t Veer P, Moreno LA; HELENA study group. Socioeconomic factors are associated with folate and vitamin B12 intakes and related biomarkers concentrations in European adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence study.Nutrition Research. 2014;34(3):199-209.
  • Ristic-Medic D, Perunicic-Pekovic G, Rasic-Milutinovic Z, Takic M, Popovic T, Arsic A, Glibetic M.Effects of dietary milled seed mixture on fatty acid status and inflammatory markers in patients on hemodialysis. Scientific World Journal. 2014;2014:563576.
  • Novaković R, Cavelaars A, Geelen A, Nikolić M, Altaba II, Viñas BR, Ngo J, Golsorkhi M, Medina MW, Brzozowska A, Szczecinska A, de Cock D, Vansant G, Renkema M, Majem LS, Moreno LA, Glibetić M, Gurinović M, van’t Veer P, de Groot LC. Socio-economic determinants of micronutrient intake and status in Europe: a systematic review. Public Health Nutrition. 2014;17(5):1031-45.
  • Nikolić M, Glibetić M, Gurinović M, Milešević J, Khokhar S, Chillo S, Algis Abaravicius J, Bordoni A,   Capozzi F. Identifying Critical Nutrient Intake in Groups at Risk of Poverty in Europe: The CHANCE Project Approach. Nutrients 2014;6(4):1374-93.
  • Jovanović V, Pavićević I, Takić M, Penezić-Romanjuk A, Aćimović J, Mandić Lj. The influence of fatty acids on determination of human serum albumin thiol group. Analytical Biochemistry. 2014;448:50-7.
  • Kardum N, Takić M, Šavikin K, Zec M, Zdunić G, Spasić S, Konić-Ristić A. Effects of polyphenol-rich chokeberry juice on cellular antioxidant enzymes and membrane lipid status in healthy women. Journal of Functional Foods. 2014 July;9:89-97.
  • Ranic, M., Nikolic, M., Pavlovic, M., Buntic, A., Siler-Marinkovic, S., & Dimitrijevic-Brankovic, S. (2014). Optimization of microwave-assisted extraction of natural antioxidants from spent espresso coffee grounds by response surface methodology. Journal of Cleaner Production, 80(0), 69-79.
  • Kardum N, Konić Ristić A, Savikin K, Spasić S, Stefanović A, Ivanišević J, Miljković M. Effects of polyphenol-rich chokeberry juice on antioxidant/pro-oxidant status in healthy subjects. Journal of Medicinal Food. 2014 Mar 20;doi:10.1089/jmf.2013.0135.
  • Savikin K, Menković N, Zdunić G, Pljevljakušić D, Spasić S, Kardum N, Konić-Ristić A. Dietary supplementation with polyphenol-rich chokeberry juice improves skin morphology in cellulite. Journal of Medicinal Food. 2014 Jan 16;doi:10.1089/jmf.2013.0102.
  • Zec M, Srdic-Rajic T, Krivokuca A, Jankovic R, Todorovic T, Anđelkovic K, Radulovic S. Novel Selenosemicarbazone Metal Complexes Exert Anti-Tumor Effect Via Alternative, Caspase-Independent Necroptotic Cell Death. Medicinal Chemistry. 2014 Mar 27; Epub ahead of print
  • Ranić, A. Konić – Ristić, M. Takić, M. Glibetić, Z. Pavlović, M. Pavlović, S. Dimitrijević – Branković. (2014). Nutrient profile of black coffee consumed in Serbia: filling a gap in the food composition database. Journal of Food Composition and Analysis, in press.

2013

  1. Vučić V, Berti C, Vollhardt C, Fekete K, Cetin I, Koletzko B, Gurinović M, van’t Veer P. Effect of iron intervention on growth during gestation, infancy, childhood, and adolescence: a systematic review with meta-analysis. Nutrition Reviews. 2013;71(6):386-401; захвалница ИИИ 41030
  2. Ristić-Medić D, Novaković R, Glibetić M, Gurinović M. EURRECA-Estimating iodine requirements for deriving dietary reference values. Critical Reviews in Food Science and Nutrition. 2013;53(10):1051-63; захвалница ИИИ 41030
  3. Mladenović D, Hrnčić D, Rašić-Marković A, Puškaš N, Petrović S, Stanojlović O. Spectral analysis of thioacetamide-induced electroencephalographic changes in rats. Human and Experimental Toxicology. 2012;32(1):90-100.
  4. Konić-Ristić A, Srdić-Rajić T, Kardum N, Aleksić-Veličković V, Kroon P, Hollands W, Needs P, Boyko N, Hayran O, Jorjadze M, Glibetić M. Effects of bioactive-rich extracts of pomegranate, persimmon, nettle, dill, kale and Sideritis and isolated bioactives on arachidonic acid induced markers of platelet activation and aggregation. Journal of the Science of Food and Agriculture. 2013;93(14):3581-7.
  5. Lowe N, Dykes F, Skinner AL, Patel S, Warthon-Medina M, Decsi T, Fekete K, Souverein O, Dullemeijer C, Cavelaars A, Serra-Majeme L, Nissensohn M, Bel S, Moreno L, Hermoso M, Vollhardt C, Berti C, Cetin I, Gurinović M, Novaković R, Harvey L, Collings R, Hall-Moran V. EURRECA – Estimating zinc requirements for deriving reference values. Critical Reviews in Food Science and Nutrition. 2013;53(10):1110-23.
  6. Dhonukshe-Rutten R, Bouwman J, Brown K, Cavelaars A, Collings R, Grammatikaki E, de Groot L, Gurinović M, Harvey L, Hermoso M, Hurst R, Kremer B, Ngo J, Novaković R, Raats M, Rollin F, Serra-Majem L, Souverein O, Timotijevic L, Van’T Veer P. EURRECA – Evidence-based methodology for deriving micronutrient recommendations. Critical Reviews in Food Science and Nutrition. 2013;53(10):999-1040.
  7. Harvey LJ, Berti C, Casgrain A, Cetin I, Collings R, Gurinovic M, Hermoso M, Hooper L, Hurst R, Koletzko B, Ngo J, Roman Viñas B, Vollhardt C, Vucic V, Fairweather-Tait SJ. Estimating iron requirements for deriving recommendations, Dietary reference values for micronutrients. Critical Reviews in Food Science and Nutrition. 2013;53(10):1064-76.
  8. Hurst R, Collings R, Harvey LJ, King M, Hooper L, Bouwman J, Gurinovic M, Fairweather-Tait SJ. Estimating selenium requirements for deriving recommendations Dietary reference values for micronutrients. Critical Reviews in Food Science and Nutrition. 2013;53(10):1077-96.
  9. Claessens M, Contor L, Dhonukshe-Rutten R, de Groot L, Fairweather-Tait SJ, Gurinovic M, Koletzko B, van Ommen B, Raats MM, van ’t Veer P. Principles and future for deriving micronutrient recommendations , Dietary reference values for micronutrient. Critical Reviews in Food Science and Nutrition. 2013;53(10):1135-46.
  10. Lachat C, Otchere S, Roberfroid D, Abdulai A, Maria F, Seret A, Milesevic J, Xuereb G, Candeias V, Kolsteren P. Diet and Physical Activity for the Prevention of Noncommunicable Diseases in Low- and Middle-Income Countries: A Systematic Policy Review. PLOS Medicine. 2013;10(6):e1001465.
  11. Danesi F, Saha S, Kroon PA, Glibetić M, Konić-Ristić A., D’Antuono LF, Bordoni A. Bioactive-rich Sideritis scardica tea (mountain tea) is as potent as Camellia sinensis tea at inducing cellular antioxidant defences and preventing oxidative stress. Journal of the Science of Food and Agriculture. 2013;93(14):3558-6.
  12. Woodcock ME, Hollands WJ, Konic-Ristic A, Glibetic M, Boyko N, Koçaoglu B, Kroon PA. Bioactive-rich extracts of persimmon but not nettle, Sideritis, dill or kale, increase eNOS activation and NO bioavailability and decrease endothelin-1 secretion by human vascular endothelial cells. Journal of the Science of Food and Agriculture. 2013;93(14):3574-80.